Amide activation by TMSCl: reduction of amides to amines by LiAlH4 under mild conditionsReductive aminationTrimethylsilyl chlorideLithium aluminum hydrideAn expeditious and practical method for the reduction of amides to amines is reported. The method consists of activation of amides with TMSCl followed...
Although ee values were modest for acylhydrazones of alkyl ketones, good to very good enantioselectivities were achieved for those derived from aryl methyl ketones and a-keto esters. The resulting N-acylhydrazines can be reduced to the primary amine Table 7 Hydrogenation of miscellaneous C¼N...
1, the main reaction products that can be obtained from amide hydrogena- tion are either the mixture of an alcohol and the lower amine (Fig. 1a), resulting from the C–N hydrogenolysis, or the higher amine (Fig. 1b), derived from the C–O pathway. This latter pathway is more ...
Interactive 3D animations of diastereoselective ketone reduction with LiAlH4 using the Felkin-Anh model for students studying at University
The method consists of activation of amides with \\{TMSCl\\} followed by reduction with LiAlH4. Various amides/lactams including hindered amides and secondary amides gave the corresponding amines in good to excellent yields. This novel protocol has a wide substrate scope and shows good functional...
ChemInform Abstract: Amide Activation by TMSCl: Reduction of Amides to Amines by LiAlH4under Mild Conditions.amines (naphthalene compounds)amines (benzene compounds)amines (acyclic compounds)reduction, hydrogenationLiAlH4 in the presence of TmsCl as activating agent is found to be efficient to reduce...
by reduction of an imidazole ester (II) and condensn. with a thioalkylamine HS-R'-NH2 (III) in a single stage. (where R is alkyl; R1 is alkylene; R" is not defined) (I) are intermediates for medicaments having anti H2 activity such as Metiamide and cimetidine. The process is ...