Amide activation by TMSCl: reduction of amides to amines by LiAlH4 under mild conditionsReductive aminationTrimethylsilyl chlorideLithium aluminum hydrideAn expeditious and practical method for the reduction of amides to amines is reported. The method consists of activation of amides with TMSCl followed...
This is an indirect proof of the existence of imine intermediates in the C–O cleavage pathway. It has also been proposed that these products can be formed by the transamidation of the starting amide with the higher amine followed by hydrogenation27. In addition to the generally accepted ...
The Ir/josiphos-catalyzed hydrogenation of pyrazine amide S16 occurred with up to 78% ee (entry 10.1) and very recently the Ir-catalyzed hydrogenation of pyridine derivatives S17 with electron-withdrawing substituents 2-position using P-phos, MeO-biphep was reported with very Author's personal ...
These compounds have a lower side-effect profile and are useful in compositions and products for use in treatment of a variety of conditions including depression, fibromyalgia, anxiety, panic disorder, agoraphobia, post traumatic stress disorder, premenstrual dysphoric disorder, attention deficit disorder...
Amide activation by TMSCl: reduction of amides to amines by LiAlH4 under mild conditions An expeditious and practical method for the reduction of amides to amines is reported. The method consists of activation of amides with TMSCl followed by r... B Ravinder,S Rajeswar Reddy,A Panasa Reddy...
Interactive 3D animations of diastereoselective ketone reduction with LiAlH4 using the Felkin-Anh model for students studying at University
Amide activation by TMSCl: reduction of amides to amines by LiAlH4 under mild conditionsdoi:10.1016/j.tetlet.2013.06.144Reductive aminationTrimethylsilyl chlorideLithium aluminum hydrideAbstract An expeditious and practical method for the reduction of amides to amines is reported. The method consists of...
HOMOGENEOUS AMIDE HYDROGENATION 9doi:10.1002/9781118354520.ch01D.L. DoddsD.J. Cole-HamiltonJohn Wiley & Sons, Inc.Dodds, D. L.; Cole-Hamilton, D. J., Catalytic Reduction of Amides Avoiding LiAlH4 or B2H6. In Sustainable Catalysis: Challenges and Practices for the Pharmaceutical and Fine ...
In the synthesis of l-phenyl-5-substituted amino-4-pyrazole N-alkyl amide,it was found for the first time that one of the two aromatic amido groups in the moleculeof 1-phenyl-5-benzoyl amino-4-pyrazole N-alkyl amide was reduced selectively by LiAlH4.new conclusion was drawn after...
(where R is alkyl; R1 is alkylene; R" is not defined) (I) are intermediates for medicaments having anti H2 activity such as Metiamide and cimetidine. The process is simpler to carry out and gives better yields than known methods. The reducing agent is pref. a metal hydride, esp LiAlH4...