Amide activation by TMSCl: reduction of amides to amines by LiAlH4 under mild conditionsReductive aminationTrimethylsilyl chlorideLithium aluminum hydrideAn expeditious and practical method for the reduction of amides to amines is reported. The method consists of activation of amides with TMSCl followed...
It has also been proposed that these products can be formed by the transamidation of the starting amide with the higher amine followed by hydrogenation27. In addition to the generally accepted mechanism involving hemiaminal formation, some alternatives have been suggested based on indirect obser- ...
The Ir/josiphos-catalyzed hydrogenation of pyrazine amide S16 occurred with up to 78% ee (entry 10.1) and very recently the Ir-catalyzed hydrogenation of pyridine derivatives S17 with electron-withdrawing substituents 2-position using P-phos, MeO-biphep was reported with very Author's personal ...
Interactive 3D animations of diastereoselective ketone reduction with LiAlH4 using the Felkin-Anh model for students studying at University
Amide activation by TMSCl: reduction of amides to amines by LiAlH4 under mild conditionsdoi:10.1016/j.tetlet.2013.06.144Reductive aminationTrimethylsilyl chlorideLithium aluminum hydrideAbstract An expeditious and practical method for the reduction of amides to amines is reported. The method consists of...
ChemInform Abstract: Amide Activation by TMSCl: Reduction of Amides to Amines by LiAlH4under Mild Conditions.amines (naphthalene compounds)amines (benzene compounds)amines (acyclic compounds)reduction, hydrogenationLiAlH4 in the presence of TmsCl as activating agent is found to be efficient to reduce...