I are prepd. via the corresp. co-acid amide by (a) reducing e.g. with LiAlH4, and (b) oxidising the novel 1-aryl substd. aminoalkan-1-ols, e.g. with MnO2.MARUYAMA, ISAMU, MINOOYAMAMOTO, HISAO, NISHINOMIYANAKAO, MASARUKATAYAMA, SHIGENARI, TAKARAZUKASASAJIMA, KIKUO...
第八章羧酸carboxylicacid及其衍生物 第八章羧酸(carboxylicacid)及其衍生物 结构通式：R-COOH 常见的羧基(carboxyl)书写方式 COOH CO2H O O C OH OH 第一节羧酸 1.羧基的结构 ❖羧基的结构特征:OCOH oRc oH 羧基碳为sp2杂化 羧基p-p共轭对其结构和性质的影响 键长平均化 羰基不典型---不利于羰基的亲核...
Amide + LiAlH4 amine Amide +Br2 /NaOH amine WITH ONE LESS C! Hoffman rearrangement takes an AMIDE and reacts it with ___ to form a AMINE with one less C Br2/NaOH Hoffman rearrangement removes which carbon from an amide to form an amine? Carbonyl carbon NaBH4 reacts with acid chlorides...
Trichloroacetic acid is a strong organic acid with a dissociation constant K = 3 × 10-2. It has lively chemical properties. Its sodium salt is easily subject to decarboxylation into chloroform. It will be reduced to alcohol upon coming across LiAlH4. It can have halogen replacement reaction ...
It will be reduced to alcohol upon coming across LiAlH4. It can have halogen replacement reaction with KBr: View all Application Trichloroacetic acid can be used as pharmaceutical raw materials, herbicides (potassium trichloroacetate and sodium trichloroacetate, etc.), textile dyeing auxiliaries, ...
9b,c Commercially available CrCl2 is often used, but several cases have been reported where selectivity is substantially better when CrCl2 is generated via the LiAlH4 reduction of CrCl3. Other methods of generating CrCh in situ lead to crotylchromium reagents that show diminished stereosel...
(4R,5S)-5-(3-((tert-butyldiphenylsilyl)oxy)prop-1-yn-1-yl)-3-((4- nitrophenyl)sulfonyl)-4-(((R)-1-tosylindolin-3-yl)methyl) oxazolidin-2-one (16) To a solution of oxazolidinone 15 (8.50 g, 12.7 mmol) in tetrahydrofuran (100 ml) was added lithium diisopropylamide (0.870 M...
The enzymatic optical resolution of (rac)-(IV) by means of Pseudomonas fluorescens affords the chiral hydroxylactone (-)-(V), which is reduced with LiAlH4 in refluxing THF to provide the lactol (VI). The oxidation of (VI) with NaIO4 in ethyl ether/water gives the chiral carbaldehyde (...
naphthalene-1-sulfonic acid {4-[(4-aminoquinazolin-2-ylamino)methyl]-cyclohexylmethyl}amide hydrochloride (CGP 71683A)), MC4 agonists (e.g. 1-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid [2-(3a-benzyl-2-methyl-3-oxo-2,3,3a,4,6,7-hexahydropyrazolo[4,3-c]pyridin-5-yl)-1...
LiAlH4 (0.0117 mol) was added portionwise at 0° C. to a solution of (±)-ethyl (A)-β-[4-[[(3,4-dimethoxyphenyl)acetyl]amino]phenyl]-α-methyl-1 H-imidazol-1-propanoate (0.0117 mol) in THF (78 ml). The mixture was allowed to warm to RT overnight and then cooled to 0° C...