WES analyses did not identify potential gene modifiers that could explain the variability of penetrance between father and son. Nonetheless, we conclude that the RASA1 mutation is responsible for the aberrant lymphatic architecture and functional abnormalities, as visualized...
Especially, miR-223 will implicate as an alternative target for tumour inhibition in CRC patients with a K-RAS mutation because upregulated miR-223 is found in almost all CRC patients with both wild-type K-RAS and K-RAS mutations. Additional findings on miRNA regulation of the gene expression...
Therefore, we hypothesized that RASA1, an important member of the RAS-GAP family, which is significantly down-regulated in colon cancer, may negatively regulate the RAS signaling pathways and act as a tumor suppressor gene. Indeed, we found that RASA1 up-regulation inhibited cell proliferation an...
Review for "Parkes‐Weber syndrome related to RASA1 mosaic mutation" Background Maternally Expressed Gene 3 ( MEG3 ) is expressed at low levels in placental villi during preeclampsia; however, its roles in unexplained recurr... J López-Gutiérrez 被引量: 0发表: 2020年 RASA1 loss in a BRAF...
The two CRC cell lines (SW480 and SW620) used in this study have one thing in common: there is a G > A mutation in codon 273 of the p53 gene, resulting in an Arg > His substitution. We speculated that the functions of miR-335-5p in CRC cell lines are correlated with the ...
The small, membrane-tethered G-protein Ras plays an important role in many cellular processes, including growth, differentiation, and survival (Wennerberg et al.2005). Ras acts as a molecular switch and is bound to GDP in its inactive state, and GTP in its active state. When Ras is active...
Mu-DdPCR™ WT for RASA1 p.N838Mfs*4 c.2513del 产品信息添加产品+ 产品编号 产品名称 期望单价 预购数量 操作 CBP01006Mu-DdPCR™ WT for RASA1 p.N838Mfs*4 c.2513del移除 询价说明 联系人: 企业名称: 手机: 邮箱: 验证码: 提交信息
Mu-DdPCR™ WT for RASA1 p.N838Mfs*4 c.2513del 产品信息添加产品+ 产品编号 产品名称 期望单价 预购数量 操作 CBP01006Mu-DdPCR™ WT for RASA1 p.N838Mfs*4 c.2513del移除 询价说明 联系人: 企业名称: 手机: 邮箱: 验证码: 提交信息
In this context, molecular testing of RASA1 gene mutation in relatives may help to better manage the family. All arteriovenous malformations are however not accessible to such procedures. In addition, these therapeutic procedures may result in potential side effects and complications. A couple was ...
Phenotypic variability in a family with capillary malformations caused by a mutation in the RASA1 gene. de Wijn RS,Oduber CE,Breugem CC,et al. Eur J Med Genet . 2012de Wijn RS, Oduber CnEU, Breugem CC, Alders M, Hennekam RCM, van der Horst CMAM. Phenotypic variability in a family...