Gonadotropin-releasing hormone (GnRH) derived peptide drugs (Fig.4b): GnRH is a peptide containing 10 amino acids that is produced by GnRH neurons in the hypothalamus52. Modification of the native sequence of G
The graph displays the proportion of TCR sequence reads containing the BV9–Y/FSTDTQ–BJ2-3 motif in paired blood and synovial fluid of three Ankylosing Spondylitis patients. Level of detection (LoD) of blood samples is indicated by a dashed line and is the median proportion of a single ...
ASC apoptosis-associated speck-like protein containing a CARD Atg14L autophagy-related protein 14 L BAD Bcl-2-associated agonist of cell death Bcl-2 B-cell lymphoma 2 Beclin-1 Bcl-2-interacting coiled-coil protein 1 BH3 Bcl-2- homology 3 domain of BAD BTB/POZ Brick-a-brac, Tramtrack...
5.2. Short Difficult Peptide Synthesis Although many peptides are routinely synthesized by SPPS, a certain kind of peptides is still difficult to be prepared. Such peptides are called "difficult sequence-containing peptides" [145]; even pentapeptides such as Ac-Val-Val...
site-specifically incorporated ncAAs containing PEG4, PEG8, and PEG12 chains by suppressing a quadruplet codon using a cell-free translation system253. Tada et al. used a similar strategy to introduce longer PEG chains ranging from PEG4 to PEG24 into polypeptides by suppressing an amber stop ...
Sequences containing the K440P mutation (Cluster 3, Fig. 1C) could not be produced due to protein precipitation during purification: it is likely that the helix-breaking Pro residue disrupts the structure of the protein leading to instability. The consensus sequence lacking the K440P ...
Several cancer therapies are being developed, and given the variability of different cancer types, the goal of these therapies is to remove the invasive tu
also discuss selection of a zinc finger protein to bind to a target site encompassing a site of a common mutation in the oncogene ras. The target site within ras was thus constrained by the position of the mutation.The present application is related to copending application Ser. No. 09/229...
p53 derived from human tumour cell lines and containing distinct point mutations can be activated to bind its consensus target sequence Oncogene, 10 (1995), pp. 881-890 View in ScopusGoogle Scholar Oberosler et al., 1993 P. Oberosler, P. Hloch, U. Ramsperger, H. Stahl p53-catalyzed anne...
The present invention relates to peptides and derivatives thereof having laminin-like activity. The invention further relates to pharmaceutical compositions containing these peptides, to antibodies ef