1. RALA蛋白的基本信息 RALA(Ras-like GTPase A)是小GTPase超家族中的一员,与Ras蛋白同源。RALA在细胞内参与多种信号传导通路,调 控一系列生物学过程,包括细胞增殖、分化、囊泡运输和细胞骨架动态调节。 目录号 PA1000-2651 蛋白功能: RALA作为一种GTP结合蛋白,在GTP结合和水解的循环中切换其活性状态。它通过与...
论文--毕业论文 文档标签: RasRASlikeras 系统标签: rasgtpaselike �.BiochimicaetBiophysicaActa13331997M19–M31Mini-ReviewRas-likeGTPasesJohannesL.Bos)LaboratoryforPhysiologicalChemistry,UtrechtUni˝ersity,Uni˝ersiteitsweg100,3584CGUtrecht,TheNetherlandsReceived28April1997;accepted12May19971.IntroductionTh...
Piddini E,Schmid JA,de Martin R,et al.The Ras-like GTPase Gem is involved in cell shape remodelling and interacts with the novel kinesin-like protein KIF9. EMBO Journal . 2001Piddini, E., Schmid, J. A., de Martin, R. and Dotti, C. G. (2001) The Ras-like GTPase Gem is ...
Evolution of the Rho family of ras-like GTPases in eukaryotes. GTPases of the Rho family are molecular switches that play important roles in converting and amplifying external signals into cellular effects. Originally ... Anthony,Boureux,Emmanuel,... - 《Molecular Biology & Evolution》...
The Ras-like GTPase Gem is involved in cell shape remodelling and interacts with the novel kinesin-like protein KIF9 Gem belongs to the Rad/Gem/Kir (RGK) subfamily of Ras-related GTPases, which also comprises Rem, Rem2 and Ges. The RGK family members Ges and Rem have been... Eugenia...
星号表示相同氨基酸,两点表示相似氨基酸,一点表示相似性略次的氨基酸 Era蛋白是原核细菌生长所必需的高度保守的GTPase酶.在DNA复制、蛋白质翻译以及细胞周 期调控中发挥重要作用。研究者们利用大量的Era蛋白保守结构域的突变体或缺失体研究其细胞功 能1141.其中还涉及不同细菌之间的era基因的突变互补实验.这也进一步说明...
Rab3A is a small, Ras-like GTPase expressed in neuroendocrine cells, in which it is associated with secretory vesicle membranes and regulates exocytosis. U... WH Brondyk,CJ Mckiernan,KA Fortner,... - 《Molecular & Cellular Biology》 被引量: 342发表: 1995年 Evidence for expression of a Ra...
We now report on the evolution of both the Ras-like small GTPases as well as the GTPase activating proteins (GAPs) for Ras-like small GTPases. We performed an in depth phylogenetic analysis in 64 genomes of diverse eukaryotic species. These analyses revealed that multiple ancestral Ras-like...
RAS-GTPase-activating proteinRASAL1RAS signaling is frequently deregulated in human neoplasms. However, RAS mutations have been found in only a small proportion of human gastric cancers, implicating other mechanisms in the activation of RAS signaling in gastric tumorigenesis. We have previously reported...
Since there is a GTPase-activating protein for the rho proteins stimulating the GTPase activity of the rho proteins in mammalian tissues, the rho proteins appear to be regulated at least by GTPase-activating protein and GDI in a dual manner....