Notably, no effect on ribosome assembly, protein synthesis or bacterial susceptibility to protein synthesis inhibitors was observed upon depletion of EraMT in Mtb H37Ra, further indicating a divergent role of Era GTPase in mycobacteria.doi:10.1099/mic.0.001200Nisheeth Agarwal...
2.3真核植物ERG蛋白的特点Blast结果显示,真核植物中也存在Era的同源蛋白,命名为ERG(ERA—likeGTPase)tl习。有关ERG蛋白的研究,迄今唯一报道的是金鱼草的ERG蛋白。该蛋白的eDNA包含l269bp的阅读框,编码一个423aa的48KD的蛋白质。N端有保守的GTPase结构域,其中超过290aa的区域覆盖了GTP嬲edomain【n堋。经计算机...
Structure and activation mechanism of RAS and RAF kinase in the RAS/RAF/MAPK signal cascade.aRAS upstream components. Various mitogens including TGF-α, EGF, VEGF, and PDGF-β bind to their own receptors and lead to RAS activation and subsequent stimulation of the MAPK pathway.bGTPase cycle. ...
Rab3A is a small, Ras-like GTPase expressed in neuroendocrine cells, in which it is associated with secretory vesicle membranes and regulates exocytosis. U... WH Brondyk,CJ Mckiernan,KA Fortner,... 被引量: 0发表: 0年 a Multicopy Suppressor for a Cold-Sensitive Mutant of Era, an Essentia...
Moreover, β-arrestins bind the small GTPase ARF6 which also aids in recruiting AP-2 and clathrin to regulate receptor internalization16,17.β-arrestins have also been shown to act as signaling adaptors by recruiting signaling proteins, notably elements of the MAPK cascade such as Raf-1, MEK...
Wild-type RAS isoforms have intrinsic, albeit weak, hydrolytic (GTPase) activity and can, therefore, self-inactivate; however, RAS-GAPs stimulate this activity dramatically11,12,13,14. Indeed, the GAPs increase RAS GTPase activity fivefold relative to the intrinsic rate12. Hence, within cells, ...
(GAPs) that is necessary for their proper functions. Upon upstream stimuli, GEFs activates Ras proteins by promoting GDP to GTP exchange, which results in conformational changes. As intrinsic GTPase activity of Ras proteins are relatively slow, their inactivation needs GAPs that foster their GTP ...
EGFR, epidermal growth factor receptor; GM-CSF, granulocyte monocyte-colony stimulating factor; HR, homologous recombination; IGF, insulin-like growth factor; PKC, protein kinase-C; ROS, reactive oxygen species; SHH, sonic hedgehog; TCA cycle, tri-carboxylic acid cycle; VEGF, vascular endothelial ...
Oncogenic mutations in the small GTPase RAS contribute to ~30% of human cancers. In a Drosophila genetic screen, we identified novel and evolutionary conserved cancer genes that affect Ras-driven tumorigenesis and metastasis in Drosophila including confirmation of the tetraspanin Tsp29Fb. However, it...