Although there have been no reports of the prevalence of these alterations in Wilms tumors, overexpression of the N-myc and insulin-like growth factor-II (IGF-II) genes have been observed, and alteration of another tumor suppressor gene (WT1) has been demonstrated.Methods. Forty-four Wilms...
29.Ohtsubo K, Watanabe H, Yamaguchi Y, Hu YX, Motoo Y, Okai T, Sawabu N. Abnormalities of tumor suppressor gene p16 in pancreatic carcinoma: immunohistochemical and genetic findings compared with clinicopathological parameters.J Gastroenterol. 2003;38:663-671.[PubMed][DOI] ...
Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7. Cell 61, 407–417 (1990). Article CAS PubMed Google Scholar Li, H. et al. Growth inhibitory effect of wild-type KRAS2 gene on a colonic ...
Fenton SL, Dallol A, Agathanggelou A, Hesson L, Ahmed-Choudhury J, Baksh S, Sardet C, Dammann R, Minna JD, Downward J, Maher ER, Latif F (2004) Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene....
Additionally, RASA1 gene expression has also been described as reduced in hepatocellular carcinoma, leading to aberrant Ras activation. However, loss-of-function mutation of RASA1 is not common in cancer. Instead, another RasGAP, the neurofibromin protein encoded by the NF1 tumor suppressor gene...
最初发现的Hippo信号通路中的成员有:Ste20 Ser/Thr激酶Hippo(Hpo)、WW结构域蛋白Salvador(Sav)、NDR家族蛋白激酶Warts (Wts) 和接头蛋白 Mob-as-tumor-suppressor(Mats),以上四个成员也是该信号通路中最核心的几个因子,研究发现这四个...
Legius syndrome is a recently recognized, milder form of neurofibromatosis type 1, in which the NF1 gene is intact, but, instead, loss-of-function mutations occur in SPRED1, a previously known suppressor of RAS/MAPK signaling. SPRED stands for Sprouty-related EVH1-domain containing protein (Bre...
Ras gene and its pathways can be detected in many human tu-mors. Ras-GTPase activating proteins (Ras-GAPs) can be seen as the products of a tumor suppressor gene. It can acti-vate the GTP enzyme and hydrolyze GTP, leading to Ras protein inactivation through GTP to GDP conversion, so as...
It plays an important role in the regulation of cell proliferation and has a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes in colorectal cancer cells in a ZNF304-dependent manner. Mutations in the gene can result in leukemia acute myelogenous, ...
(2001) Epigenetic inactivation of the RASSF1A 3p21.3 tumor suppressor gene in both clear cell and papillary renal cell carcinoma. Cancer Res. 61, 7277-7281. Neufeld, T.P., de la Cruz, A.F., Johnston, L.A. and Edgar, B.A. (1998) Coordination of growth and cell division in the ...