tumor suppressor genecell cycleinduction of tumor cell differentiationand , it has been found that some molecules of the same class named CKI (cyclin-dependent kinase inhibitor) also play an important role in the inhibition of tumorigenesis and the tumor progression. In the KIP and INK4 families...
The tumor suppressor p53 performs similar functions to enable DNA repair and to maintain genomic stability [36]. Cell-cycle arrest by FoxO and p53 occurs through inducing their target genes such as p16, p21WAF1/CIP1 and p27KIP1 [63]. FoxO and p53 orchestrate apoptosis through multiple mechani...
Graphical Abstract. Credit:Cell Reports(2022). DOI: 10.1016/j.celrep.2022.111821 A research team from LKS Faculty of Medicine, the University of Hong Kong (HKUMed) discovered that somatic deletion of a tumor suppressor gene AKTIP promotes luminal breast cancer development and resistance to endocrine...
The Wilms' tumor suppressor gene, WT1, encodes a transcription of the Cys2-His2 zinc finger type. Loss of WT1 gene function has been implicated in the development of malignancies including Wilms' tumor and acute leukemias. We have shown ... S I Smith,M Down,AW Boyd,... - 《Cancer Res...
Thus, it was concluded that miR-204 functions as a tumor suppressor gene, at least partly by suppressing CYP27A1 in glioblastoma. 展开 关键词: glioblastoma cytochrome P450 family 27 subfamily A polypeptide 1 microRNA-204 proliferation DOI: 10.3892/ol.2018.8846 年份: 2018 ...
A new tumor suppressor gene for breast cancer in mice byTokyo Institute of Technology The ER alpha expression of in Nrk mutant mammary epithelial cells. Credit: The American Journal of Pathology Researchers at Tokyo Institute of Technology revealed a role for an X-linked protein kinase Nrk in te...
miR‑218 functions as a tumor suppressor gene in cervical cancer Molecular Medicine Reports (2020) - Figure 4:Overlaps between images which should show different cells/experiments. There are some differences in intensity. Identified and labelled withImageTwin.ai...
et al. Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKα kinases. Genes Dev. 21, 562–577 (2007). Article PubMed PubMed Central CAS Google Scholar Parsa, R., Yang, A., McKeon, F. & Green, H. ...
A recent paper reports that 50% of these carcinomas contain mutations in the E-cadherin gene, resulting in the destruction of the calcium-binding sites of E-cadherin, and providing strong in vivo evidence that alterations in E-cadherin play a major role in the development of this particular ...
The adenomatous polyposis coli (APC) gene is a key tumor suppressor gene. Mutations in the gene have been found not only in most colon cancers but also in some other cancers, such as those of the liver. The APC gene product is a 312 kDa protein that has multiple domains, through which...