抑癌基因TP53,也会影响记忆与学习 约半数的癌症病患,其癌细胞内TP53基因都已发生突变而功能异常。TP53是细胞修复DNA损伤所必须,有预防基因突变及癌症发生的功能而是一“抑癌基因”(Tumor suppressor gene)。然而最新研究显示TP53的重要性可能不仅于此,美国伊利诺大学的科学家发现,它也会影响动物的学习及行为,甚至与自闭...
Furthermore, we demonstrate in this work that the TP53 gene is an informative model with which to study the molecular mechanisms of mutagenesis in the human genome.Claude Caron De FromentelUnité d'Oncologie MoléculaireThierry SoussiUnité d'Oncologie MoléculaireGenes, Chromosomes and Cancer...
参考资料: [1]https://medlineplus.gov/genetics/gene/tp53/ [2]https://www.cancer.org/cancer/understanding-cancer/genes-and-cancer/oncogenes-tumor-suppressor-genes.html [3] https://www.cancer.net/cancer-types/li-fraumeni-syndrome [4]h...
[1]https://medlineplus.gov/genetics/gene/tp53/ [2]https://www.cancer.org/cancer/understanding-cancer/genes-and-cancer/oncogenes-tumor-suppressor-genes.html [3] https://www.cancer.net/cancer-types/li-fraumeni-syndrome [4]https://dailynews.ascopubs.org/do/p53-most-frequently-muted-gene-canc...
Tumor protein 53 (TP53) is a tumor suppressor gene responsible for a host of protective mechanisms aimed at species survival. 中文解释 肿瘤蛋白 53 (TP53) 是一种肿瘤抑制基因,负责许多旨在物种生存的保护机制。 参考文献 [1]. Hey-Joo Kang, et al. p53 and reproduction. Fertil Steril. 2018 Jan;...
[13] Sill H, Goldman JM, Cross NC. Homozygous deletions of the p16 tumor-suppressor gene are associated with lymphoid transformation of chronic myeloid leukemia. Blood. 1995. 85(8): 2013-6. [14] Hof J, Krentz S, van Schewick C, et a...
[1] https://medlineplus.gov/genetics/gene/tp53/ [2]https://www.cancer.org/cancer/understanding-cancer/genes-and-cancer/oncogenes-tumor-suppressor-genes.html [3] https://www.cancer.net/cancer-types/li-fraumeni-syndrome [4]https://dailynews.ascopubs.org/do/p53-most-frequently-muted-gene-ca...
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes ...