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RAS genes are the most commonly mutated oncogenes in cancer, but effective therapeutic strategies to target RAS-mutant cancers have proved elusive. A key aspect of this challenge is the fact that direct inhibition of RAS proteins has proved difficult, leading researchers to test numerous alternative...
in lung tumour cell lines expressing Kras(G12D) and lacking p53, p53 restoration led to NF-B inhibition. Furthermore, the inhibition of NF-B signalling induced apoptosis in p53-null lung cancer cell lines. Inhibition of the pathway in lung tumours in vivo, from the time of tumour initiatio...
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Int J Cancer 58 : 174 – 178 .Watanabe M, Shiraishi T, Yatani R, Nomura AMY and Stemmermann GN (1994): International comparison on ras gene mutations in latent prostate carcinoma. Int J Cancer 58: 174–178International comparison on ras gene mutations in latent prostate carcinoma - Watanabe...
接下来,识别了Cancer Gene Census标注的已知的突变基因,然后关注在COSMIC中标注的突变的热点区域,以识别注释到该通路的事件。23例复发样本中有15例包含符合这些标准的体细胞突变。此外,三个复发样本显示涉及RAS-MAPK通路基因的结构改变。在23例复发样本中的18例(78%)中检测到该通路的畸变,所有的改变显示通路激活(...
Integrating bulk and single-cell transcriptomic data from mouse and human datasets with functional studies in vivo unravels a unique MYC/RAS co-activation signature associated with prostate cancer metastasis. Finally, we identify a gene signature with prognostic value for time to metastasis and ...
英文名称:Human RAS cancer gene family member RAB5A elisa kit 用途:科研实验 产地:上海 品牌:睿创 包装规格:96T/48T 标记物:HRP标记物 样本:血清,血浆,唾液,尿液,组织,细胞上清,裂解液等 检测方法:酶联免疫法 应用:定性/定量/酶活检测 检测限:详见说明书 ...