Ras-Related Small GTPasesColin K. HillParvesh KumarElizabeth K. BalcerKubiczekMarie FernetJanet HallYoulia M. KirovaOliver WeigertMartin DreylingJames P. B. O’ConnorAlan Jackson
Small GTPases act as molecular switches in intracellular signal-transduction pathways. In the case of the Ras family of GTPases, one of their most important roles is as regulators of cell proliferation, and the mitogenic response to a variety of growth factors and oncogenes can be blocked by...
Ras-Related Small GTPases 来自 growkudos.com 喜欢 0 阅读量: 14 作者: CK Hill,P Kumar,EK Balcerkubiczek,M Fernet,J Hall,YM Kirova,O Weigert,M Dreyling,JPB O’Connor,A Jackson 展开 年份: 2011 收藏 引用 批量引用 报错 分享 全部来源 求助全文 growkudos.com 研究点推荐 Small GTPases ...
A gene on chromosome 18p11.22 that encodes a member of the Rab subfamily of Ras-related small GTPases, which is involved in vesicle trafficking. Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved. Want to thank TFD for its existence?Tell a friend about us, add a link...
The RAS subfamily of small GTPases consists of 35 members and includes the archetypal oncoproteins H-, K- and N-RAS, along with related GTPases of the RAP, RAL, RIT and RHEB families5. Effectors bind activated RAS GTPases through RAS Association domains (RAs) or RAS Binding Domains (RB...
NO plays a key role in tissue function during hypoxia by regulating the S-nitrosylation of target proteins [93,94], such as Ras and Ras-related GTPases [64]. In particular, under hypoxic conditions, p21Ras is activated by S-nitrosylation initiating the translocation of H-Ras in the ...
产品介绍Rab17 belongs to the Rab family of small Ras-like GTPases. It is specifically expressed in epithelial cells and is upregulated during cell polarization. Immunofluorescence staining studies indicate that Rab17 is associated with the perinuclear recycling endosome in nonpolarized epithelial cells...
Small GTPaseRas, Rho, Cdc42 and Rac G-proteins have been examined in diverse fungi.These Ras superfamily GTPases have distinct roles in fungal filamentous growth.The localization of Ras, Rho, Cdc42 and Rac G-proteins differs during hyphal growth....
immunofluorescence-conjugated noroviral capsid protein VP1 and a confocal microscope. The up-regulation of Ras GTPases such Rab5A and Rab6A was found to be implicated in norovirus gastroenteritis, as revealed by proteomic profiling. Consequently, the recognition of Ras-related proteins can lead to ...
ROMANO D, MAGALON K, CIAMPINI A, TALET C y cols.: Differential involvement of the Ras and Rap1 small GTPases in vasoactive intestinal and pituitary adenylyl cyclase activating polypeptides control of the prolactin gene. J Biol Chem, 278:51386-94, 2003....