SynGAP (Synaptic Ras-GTPase Activating Protein) | 基本信息 更多信息 中文名称: 中文同义词: 英文名称: SynGAP (Synaptic Ras-GTPase Activating Protein) 英文同义词: SynGAP (Synaptic Ras-GTPase Activating Protein) CAS号: 分子式: 分子量: 0 EINECS号: 信息错误报告 您的Email: 按国家浏览...
Here, we demonstrate that SynGAP, a synaptic Ras GTPase activating protein, is essential for the anatomical development of whisker-related patterns in the developing somatosensory pathways in rodent forebrain. Mice lacking SynGAP show only partial segregation of barreloids in the thalamus, and ...
we show that the synaptic Ras GTPase-activating (RASGAP) protein 1 (SYNGAP1, a top ASD risk gene) is expressed within the apical domain of human radial glia cells (hRGCs). In a human cortical organoid model ofSYNGAP1haploinsufficiency, we find dysregulated cytoskeletal dynamics that impair the...
The spread of Ras activity triggered by activation of a single dendritic spine. Science 321, 136–140 (2008). Article CAS PubMed PubMed Central Google Scholar Chen, H. J., Rojas-Soto, M., Oguni, A. & Kennedy, M. B. A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited...
SynGAP is a Ras-GTPase activating protein highly enriched at excitatory synapses in the brain. Previous studies have shown that CaMKII and the RAS-ERK pathway are critical for several forms of synaptic plasticity including LTP. NMDA receptor-dependent calcium influx has been shown to regulate the ...
Two other calmodulin-binding proteins included Pollux, a protein with similarity to a portion of a yeast Rab GTPase activating protein, and Calossin, an enormous protein of unknown function conserved throughout animal phylogeny. Thus, it appears that calmodulin functions as a Ca2+ sensor for a ...
Transferrin, AP2 and dynamin-1; possible role of tau in early stages of CME Constitutive CME is required for plasma membrane protein and lipid turnover, endocytosis of activated growth-factor receptors, low-density lipoprotein and iron-saturated transferrin uptake [48,79,302]. Tau is capable of...
Neurofibromatosis type 1 (NF1), a genetic disease that affects 1 in 3,000, is caused by loss of a large evolutionary conserved protein that serves as a GTPase Activating Protein (GAP) for Ras. Among Drosophila melanogaster Nf1 (dNf1) null mutant phenotypes, learning/memory deficits and ...
the nucleus of neurons are still poorly characterized [173]. Estrogens increase the concentration of filamentous actin in spines and strongly enhance its polymerization in association with LTP. A study of the origins of these effects showed that estrogens activate the small GTPase RhoA and ...
SynGAP, H-Ras, PSD-95, long-term potentiation, hippocampus, spatial learningAt excitatory synapses, the postsynaptic scaffolding protein postsynaptic density 95 (PSD-95) couples NMDA receptors (NMDARs) to the Ras GTPase-activating protein SynGAP. The close association of SynGAP and NMDARs suggests...