W. (2001) Transient cerebral ischemia increases tyrosine phosphorylation of the synaptic Ras-GTPase activating protein, SynGAP. J. Cereb. Blood Flow Metab. (in press).Pei, L., Teves, R.L., Wallace, M.C. & Gurd,
we show that the synaptic Ras GTPase-activating (RASGAP) protein 1 (SYNGAP1, a top ASD risk gene) is expressed within the apical domain of human radial glia cells (hRGCs). In a human cortical organoid model ofSYNGAP1haploinsufficiency, we find dysregulated cytoskeletal dynamics that impair the...
A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II Neuron, 20 (1998), pp. 895-904 View PDFView articleView in ScopusGoogle Scholar Chen et al., 2008 X. Chen, C. Winters, R. Azzam, X. Li, J.A. Galbraith, R.D. Leapman, T.S. Reese Organization of...
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GEF promotes spine formation, possibly through downstream effectors such as the EphB receptor, SPAR, an inhibitory GTPase-activating protein (GAP) for Ras-related proteins (RAP) that promotes the growth of dendritic spines, and IRSp53, a downstream effector of Cdc42 small GTPase (Choi et al.,...
B. Kennedy (1998) A synaptic Ras-GTPase activating protein (pl35 SynGAP) inhibited by CaM kinase II, Neuron, 20, 895–904. Article PubMed CAS Google Scholar J. H. Kim, D. Liao, L. F. Lau and R. L. Huganir (1998) SynGAP: a synaptic RasGAP that associates with the PSD-95/...
The N-terminus projection region has been found capable of binding to synaptic vesicles, either through protein binding (Fig. 1b, [424, 503] or through direct membrane interactions [44, 265]. The proline-rich region and microtubule binding domain are capable of poly- merising F-actin, ...
Transferrin, AP2 and dynamin-1; possible role of tau in early stages of CME Constitutive CME is required for plasma membrane protein and lipid turnover, endocytosis of activated growth-factor receptors, low-density lipoprotein and iron-saturated transferrin uptake [48,79,302]. Tau is capable of...
Because of their known func- tion in synaptic plasticity [65–69], we further characterized protein phosphatase 1 regulatory subunit 1a (Ppp1r1a), Rab11, RAS protein activator like 1 (Rasal1), Ephrin B3 (Efnb3), and Rab3b by immunoblot (Figure S3D), but were unable to confirm altered ...
The spread of Ras activity triggered by activation of a single dendritic spine. Science 321, 136–140 (2008). Article CAS PubMed PubMed Central Google Scholar Chen, H. J., Rojas-Soto, M., Oguni, A. & Kennedy, M. B. A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited...