The roles of Ras and Rap1 were distinguished by their mechanism of activation, dependence on the cAMP-dependent protein kinase (PKA), and the magnitude and kinetics of their effects on ERKs. Ras was required for the early portion of ERK activation by cAMP and was activated independently of ...
Although the major mechanism governing Ras activation is through growth factors, as outlined above, Ras function can also be modulated by heterotrimeric G protein and second-messenger pathways. The ability of free βγ subunits, particularly those released from Gi, to activate Ras, was mentioned ear...
Cyclin A transcriptional suppression is the major mechanism mediating homocysteine-induced endothelial cell growth inhibition. Previously, it was reported that homocysteine (Hcy) specifically inhibits the growth of endothelial cells (ECs), suppresses Ras/mitogen-activated protein (... H Wang,XH Jiang,F...
RAS-protein activation but not mutation status is an outcome predictor and unifying therapeutic target for high-risk acute lymphoblastic leukemia David Koschut, Debleena Ray, Zhenhua Li, Emanuela Giarin, Jürgen Groet, Ivan Alić, Shirley Kow-Yin Kham, Wee Joo Chng, Hany Ariffin,...
it has been reported that SOX2 could be regulated by MAPK signaling for maintaining side population or CSCs in human NMIBC.30 Taken together, our study revealed a novel mechanism of BCa invasion and metastasis, in which RASAL2 loss could facilitate BCa cell migration, invasion, stemness and tum...
It is now shown that stimulation of the antigen receptor of T lymphocytes causes a rapid activation of p21 ras . The mechanism seems to involve a decrease in the activity of GAP, the GTPase-activating protein, on stimulation of protein kinase C. In lymphocytes, p21 ras may therefore be an...
in the understanding of the catalysis mechanism. However, alterations of 0.01 Å in the GTP geometry, below the resolution of the X-ray structure analysis, induced by protein binding and charge shifts within GTP have been shown to contribute signifi- cantly to catalysis (16, 19). Furthermore...
These results suggest a new mechanism by which mitogenic signals may influence transcription activity of the SRE by selectively promoting protein-protein interactions between SRF and the transactivator p35-C/EBPβ. 展开 关键词: blowing hall breath method decortication of lung chronic empyema DOI: ...
This study provides insights into the mechanism driving SR-BI protein turnover. Inhibitors of proteasomal (lactacystin) as well as lysosomal (bafilomycin) degradation increased SR-BI protein levels in HuH7 hepatocytes, indicating that SR-BI can be targeted to the proteasome and lysosome for ...
Protein–protein docking was performed using MOE to predict the interaction mechanism between HRas and wt and mutated RASGPR4 proteins. The most representative structures of RASGRP4 proteins was obtained by cluster analysis applied on the 20 ns MD. Dockings were performed using HRas as ligand. Co...