However, RAS mutations have been found in only a small proportion of human gastric cancers, implicating other mechanisms in the activation of RAS signaling in gastric tumorigenesis. We have previously reported that decreased expression of RAS protein activator like-1 (RASAL1), a member of the RAS...
However, RAS mutations have been found in only a small proportion of human gastric cancers, implicating other mechanisms in the activation of RAS signaling in gastric tumorigenesis. We have previously reported that decreased expression of RAS protein activator like-1 (RASAL1), a member of the RAS...
定位到目标基因启动子附近,进而启动基因转录,其中包括c-fos。 c-fos与c-Jun等蛋白结合形成AP-1 (Activator Protein-1)转录因子复合物,调节一系列含有AP-1结合位点(TRE,TPA-responsive element,序列为 TGACTCA)的基因表达。如细胞周期增殖蛋白Cyclin D1的表达。 Cyclin D1与CDK4/6形成复合物,使视网膜母细胞瘤蛋...
本文利用小鼠基因敲除、EAE模型、离体细胞定向分化和转录组测序等技术手段开展研究,结果表明GAP1家族成员Ras p21 protein activator 3 (RASA3)是pTh17产生所必需的;RASA3通过促进IRF4与E3泛素连接酶Cbl-b结合使得IRF4发生泛素化降解,减少IL-4表达,抑制Th2细胞分化,进而促进pTh17细胞分化。因此,RASA3-IRF4-Cbl-b...
et al. Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors. Oncogene 18, 813–822 (1999). Article CAS PubMed Google Scholar Dudley, D. T., Pang, L., Decker, S. J., Bridges, A. J. & Saltiel, A. R. A synthetic inhibitor ...
H. et al. Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner. J. Cell Biol. 146, 149–164 (1999). Article CAS PubMed PubMed Central Google Scholar Mitchison, T. J. & ...
activates the PI3K signaling cascades. Both the MAPK and PI3K signaling cascades can be inhibited at each kinase tier. ERK: Extracellular signal-regulated kinase; FAK: Focal adhesion kinase; GEFs: Guanine nucleotide exchange factors; MEK: Mitogen-activated protein kinase kinase; PDK1: 3-Phosphoinositi...
Rozakis-Adcock, M., Fernley, R., Wade, J., Pawson, T. & Bowtell, D. The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1.Nature363, 83–85 (1993). CASPubMedGoogle Scholar Egan, S. E. et al. Association of Sos Ras exchange protein wi...
RASA2 3q23 p.Y326C, p.Y326N, p.R511C Ras P21 Protein Activator 2 RasGAP GTPase-activating protein that binds activated G-proteins and stimulates their GTPase activity to switch the active GTP-RAS to the inactive GDP-RAS Loss of function RRAS 19q13.33 p.G39dup, p.V55 M Related ...
CALDAG-GEFI; CALDAG-GEFII; Guanine nucleotide exchange factor, calcium and DAG regulated, Rap1A; hRasGRP1; Ras activator RasGRP; RAS guanyl nucleotide releasing protein 1; RAS guanyl releasing protein 1 (calcium and DAG-regulated); RAS guanyl releasing protein 1; RASGRP; RASGRP1; GRP1_HUMAN....