Reduced expression of RAS protein activator like-1 in gastric cancer. Int J Cancer. 2011;128:1293–302.Seto M,Ohta M,Ikenoue T,et al.Reduced expression of RAS protein ac-tivator like-1 in gastric cancer. International Journal of Cancer . 2011...
Advances in Targeting the Ras/Raf/MEK/Erk Mitogen-Activated Protein Kinase Cascade with MEK Inhibitors for Cancer Therapy, Molecular Pathways, 2008 Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies, Signal Transduction and Targeted Therapy, 2023 Drugging the und...
exerting control over various facets of cellular metabolism in cancer cells.62,63Consequently, when it comes to development of anticancer drugs, the focus largely centers on three key upstream regulators and ERK protein in the ERK pathway: RAS (upstream activator of RAF), RAF (direct ...
ARAF, BRAF, and CRAF comprise the RAF kinase family, all of which share a common upstream activator, RAS [169]. ZM336372 was the first small-molecule, ATP-competitive RAF inhibitor developed, targeting CRAF in cancer [170], However, among the first-generation RAF inhibitors, only Sorafenib ...
英文名称: Rat RAS protein activator like 1(RASAL1)ELISA Kit 用途: 科研实验 产地: 上海 品牌: 科博瑞 包装规格: 96T/48T 标记物: HRP标记物 样本: 血清,血浆,唾液,尿液,组织,细胞上清,裂解液等 检测方法: 酶联免疫法 应用: 详见说明书 检测限: 详见说明书 货号: KBR-hlk5244 是否进...
别名GAP1 like protein; MRASAL; RAS GTPase activating protein like; RAS protein activator like 1 (GAP1 like); RAS protein activator like 1; RASAL; Rasal1; rasGAP activating like protein 1; RasGAP-activating-like protein 1; RASGAP1 LIKE; RASL1_HUMAN. ...
That transcriptional repression also was relieved by the double mutation S17N/E63K points to sequestration of the activator, GNRF, as a likely mechanism for inhibition of gene expression by S17N Ras here; the single and double mutations were expressed at comparable levels. Complete relief of ...
et al. A dynamic partitioning mechanism polarizes membrane protein distribution. Nat. Commun. 14, 7909 (2023). Article CAS PubMed PubMed Central Google Scholar Miao, Y. et al. Wave patterns organize cellular protrusions and control cortical dynamics. Mol. Syst. Biol. 15, e8585 (2019). ...
Rozakis-Adcock, M., Fernley, R., Wade, J., Pawson, T. & Bowtell, D. The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1.Nature363, 83–85 (1993). CASPubMedGoogle Scholar Egan, S. E. et al. Association of Sos Ras exchange protein wi...
因子2 ( Ras protein activator like 2 ,RASAL2) 、GTPase 活化 蛋白 1 ( GTPase-activating protein 1,RASA1) 、IQ 样GTPase 活化蛋 白同源体 1 ( IQ motif containing GT— Pase.activating protein homologu e 1,IQGAP1) 、IQGAP2 等,其共同特点是都含有 1 个与Ras 蛋白结合区域— — Ras...