Several lines of evidence have shown that the cell-cycle machinery, specifically the circuit cyclin D1/cyclin-dependent kinase (cdk) 4 and 6–p16–pRb, lies downstream of ras. Point mutations that activate the ras protein and its downstream cascade have been observed in human and experiment...
More recently, it has been appreciated that insulin also regulates the inactivation of this pathway, namely by uncoupling the protein complexes whose formation is required for Ras activation. This review addresses molecular mechanism which both positively and negatively regulate this mitogenic signalling ...
Several lines of evidence have shown that the cell-cycle machinery, specifically the circuit cyclin D1/cyclin-dependent kinase (cdk) 4 and 6–p16–pRb, lies downstream of ras. Point mutations that activate the ras protein and its downstream cascade have been observed in human and experimental ...
The small G proteins, like the heterotrimeric G proteins, bind guanine nucleotides, possess intrinsic GTPase activity, and cycle through GDP- and GTP-bound forms (as shown in Fig. 21-1). One unifying feature of the various classes of G protein is that the binding of GTP versus GDP ...
Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation. Angew Chem Int Ed Engl 51, 6140–3 (2012). Article CAS Google Scholar Baba, S., Hoshino, T., Ito, L. & Kumasaka, T. Humidity control and hydrophilic glue coating applied to mounted protein crystals ...
pathways could include activation of Ca2+-mediated pathways47and/or upregulation of anti-oxidant pathways, such as Nrf248,49. In addition, mutations in RAS associating proteins may work in collaboration with each other, as 36% of samples with a RAS associating protein mutation had more than ...
Cell-cycle鈥揹ependent activation of mitogen-activated protein kinase kinase (MEK-1/2) in myeloid leukemia cell lines and induction of growth inhibition and apoptosis by inhibitors of RAS signaling MA Morgan, O Dolp, CW Reuter: Cell-cycle-dependent activation of mitogen- activated protein kinase...
The small G protein Ras has been implicated in hypertrophy of cardiac myocytes. We therefore examined the activation (GTP loading) of Ras by the following ... A Chiloeches,HF Paterson,R Marais,... - 《Journal of Biological Chemistry》 被引量: 225发表: 1999年 Regulation of cell cycle molec...
6A clearly illustrate that a mixture of p120SH3 and DLC1GAP shift the elution profile of the respective protein domains to an elution volume of 10.5 ml, indicating the formation of a complex between both proteins. We next determined the inhibitory potency of p120SH3 by measuring DLC1GAP ...
Monomeric G protein Ras functions as a molecular switch linking receptor and nonreceptor tyrosine kinase activation to a number of downstream signaling pathways leading to distinct cytoplasmic or nuclear events. Each mammalian cell contains three Ras proto-oncogene coding for closely related Ras proteins...