50 In addition, patients carrying the FLT3–ITD mutation were nonresponsive to MEK inhibition, although Ras pathway activation has been previously associated with such mutations.50 A recent study where the potent MEK1/2 inhibitor trametinib was tested as a single-agent treatment with relapsed/...
We next examined to what extent the direct RAS activation in wtRAS leukemic cells affects the cell growth and viability. We tracked the cell count and cell viability of MUTZ-5 cells after treatment with pan-wtRAS-inhibitor and in comparison to treatments with other compounds that have been pre...
Using a battery of specific inhibitor/modulators of different signalling molecules, this study shows that expression and activation of MAP kinases are two unrelated processes. It was also observed that kinase (protein tyrosine and protein kinase C) inhibitor and Ca2+/calmodulin antagonist inhibit ...
别名Ras and Rab interactor 1; ras inhibitor 1; ras inhibitor; RIN1_HUMAN; Ras inhibitor JC99; ras inhibitor RIN1; Ras interaction/interference protein 1; RIN 1. 英文名称 Anti-RIN1中文名称 RAS抑制蛋白1抗体浓度1mg/1ml 规格0.1ml/100μg 0.2ml/200μg抗体来源 Rabbit 克隆类型 polyclonal 交叉反...
别名Ras and Rab interactor 1; ras inhibitor 1; ras inhibitor; RIN1_HUMAN; Ras inhibitor JC99; ras inhibitor RIN1; Ras interaction/interference protein 1; RIN 1. 研究领域细胞生物染色质和核信号神经生物学信号转导G蛋白偶联受体表观遗传学G蛋白信号 ...
Ras信号通路与突触功能和记忆密切相关[7],Ras在神经纤维瘤小鼠中的过度表达显著损害了认知记忆和突触功能[8]。然而Ras抑制是否能挽救AD小鼠突触的功能或结构损伤尚不清楚。 近期,南通大学的陈婷婷团队在Journal of Neurosciencence上发表了...
别名:Ras and Rab interactor 1; ras inhibitor 1; ras inhibitor; RIN1_HUMAN; Ras inhibitor JC99; ras inhibitor RIN1; Ras interaction/interference protein 1; RIN 1. 宿主来源:Rabbit/Mouse 克隆类型:单抗/多抗 性状:Lyophilized or Liquid(冻干粉或液体) ...
Description Salirasib is an inhibitor of prenylated protein methyltransferase (PPMTase) with Ki value of 2.6 µM. Targets PPMTase IC50 2.6 µM Quality Control Quality Control & MSDS View current batch: Purity = 99.28% COA (Certificate Of Analysis) HPLC (Retest) NMR (Nuclear Magnetic ...
VIP5年 杭州固拓生物科技有限公司 2025-05-13 KRAS G12C inhibitor 19 2649788-46-3 询价 VIP5年 河南威梯希化工科技有限公司 2025-05-13 Recombinant Human K-Ras / K-Ras Protein (His tag) ￥1950 VIP3年 上海沪震实业有限公司 2025-05-13
The increased Ras signaling may result from over-expression of wild-type Ras, over-activation of wild-type Ras, or increased activation of one or more effector pathways downstream of Ras. The tumor cells of the individual may be malignant or non-malignant. The inhibitor(s) of PKC-delt...