原文链接:Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas 这篇文章主要发表了一个通过RNA seq 数据建逻辑回归模型,用来预测Ras信号通路是否激活。 判断一个信号通路是否激活的直接方式是通过靶向测序,这样会漏掉那些靶基因没有突变或CNV但是却有突变表型的受试者(拟表型了解下...
评估Ras通路激活最直接的方法是通过Ras的靶向测序,但该方法检测不到激活的Ras表型突变体中其它基因的未知突变,而针对这类肿瘤的检测可使更多患者有靶向治疗的机会。本文编译至Cell杂志4月发表的Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas一文,介绍应用机器学习从泛癌图谱中...
Assessing the frequency, spectrum, and relation with clinical features of these mutations should permit to better evaluate the implication of Ras pathway activation. Methods: 209 children (aged 1 to 17 yrs) with B-lineage ALL were studied at diagnosis. ALL with a t(12;21) were excluded from...
[3] Cargnello, Marie, and Philippe P. Roux. "Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases." Microbiology and molecular biology reviews 75.1 (2011): 50-83. [4] Trempolec, Natalia, Natalia Dave-Coll, and Angel R. Nebreda. "SnapShot: p38 ...
pathway activation,created using fresh frozen(FF) tissues,for use with more widely available formalin fixed paraffin-embedded(FFPE) tissues.In this study,we evaluated the translation of an 18-gene RAS pathway signature score from FF to FFPE in54 CRC cases,using a head-to-head comparison of ...
Ras Signaling Pathway(1)|pathway|RAS|ras|signalingRas activates many signaling cascades. Here we illustrate some of the well-characterized cascades in a generic compilation of effector molecules. The effectors mediate Ras stimulat
Activation of Ras-ERK pathway by Fgf8 and its downregulation by Sprouty2 for the isthmus organizing activity[J]. Dev Biol, 2010,337(2):284-293.Asuka Suzuki-Hirano,Hidekiyo Harada,Tatsuya Sato,Harukazu Nakamura.Activation of Ras-ERK pathway by Fgf8 and its downregulation by Sprouty2 for the ...
Zn2+-induced ERK activation mediated by reactive oxygen species causes cell death in differentiated PC12 cells. JNK and ERK, only ERK contributes to Zn2+-induced cell death, and that ERK activation is mediated by ROS via the Ras/Raf/MEK/ERK signaling pathway... SR Seo,SA Chong,SI Lee...
Oncogenic RAS promotes the translocation of V-ATPase from intracellular membranes to the plasma membrane via a pathway that requires the activation of protein kinase A by a bicarbonate-dependent soluble adenylate cyclase. Accumulation of V-ATPase at the plasma membrane is necessary for the cholesterol...
Prevention of PC12 Cell Death by N -Acetylcysteine Requires Activation of the Ras Pathway 来自 onAcademic 喜欢 0 阅读量: 16 作者:CYI Yan,LA Greene 摘要: We propose a standardized karyotype for the raccoon (Procyon lotor; 2n = 38, FN 74) and compare it with that of the domestic cat (...