产品货号 产品规格 目录价 数量 93012ES25 25μg 1485.00 93012ES60 100μg 5065.00 93012ES76 500μg 16875.00 批量采购,请点击询价 下载产品说明书 产品说明书 FAQ COA 已发表文献 性能参数 表达区间及表达系统(Source) Recombinant Biotinylated Human P53 R175H (HLA-A*02:01) Protein is expressed from ...
(tumor protein p53) P53基因编码的是分子量约为53kDa的蛋白,P35根据其分子量大小命名的,首次是在1979年发现致瘤病毒SV40可以与该蛋白形成复合物,并且将克隆得到p53转入到细胞可引起细胞癌变,所以最初的10年普遍认为p53是抑癌基因。后来发现之前肿瘤细胞来源的p53基因突变体能够促使细胞发生转化,而野生型的p53基因则...
1 p53突变蛋白稳定,可获得显性阴性或癌性功能获得活性,从而促进恶性转化、转移和化疗耐药。2,3蛋白水解靶向嵌合体(Proteolysis targeting chimeras, PROTACs)劫持细胞泛素-蛋白酶体机制进行靶向蛋白质降解,在靶向以前无法治疗的蛋白质方面显示出相当大的前景。然而,靶向p53突变体的PROTACs尚未被报道,这可能是由于难以为...
PE-labeled Human HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC93055ES 价格电议 起批量≥1 盒 最小起订1盒 供货总量电询 发货地址上海市浦东新区 建议售价￥15565.00/盒 更新日期2025年03月25日 产品规格100μg 即时洽谈立即询价查看联系方式 收藏产品发送留言 ...
我们意外地发现,具有R175H GOF突变的KLE细胞对蛋白酶体抑制剂硼替佐米高度敏感,而具有LOF p53突变的Hec50细胞对硼替佐米具有相对抗性。 接下来,我们检查了添加组蛋白脱乙酰基酶抑制剂的影响。与单独使用硼替佐米相比,硼替佐米与HDACi LBH589(泛奥司他)的组合进一步增加了KLE细胞(R175H GOF)中的细胞杀伤力(...
CELLULAR TUMOR ANTIGEN P53 (R175H),来源于药化词典-药智数据
Despite the potential of PROTACs, limited research has been directed toward the degradation of the p53-R175H mutant protein. In this study, we developed a series of peptide-based PROTACs, leveraging known peptide ligands for both the p53-R175H mutation and the E3 ubiquitin ligase VHL. Our ...
Gain-of-function p53 mutants such as p53-R175H form stable aggregates that accumulate in cells and play important roles in cancer progression. Selective degradation of gain-of-function p53 mutants has emerged as a highly attractive therapeutic strategy to target cancer cells harboring specific p53 ...
The tumor suppressor protein p53 is among the most commonly mutated proteins across a variety of cancer types. Notably, the p53 R175H mutation ranks as one of the most prevalent hotspot mutations. Proteolysis-targeting chimeras (PROTACs) represent a class of bifunctional molecules capable of harness...
产品规格 目录价 数量 93055ES60 100μg 17365.00 批量采购,请点击询价 下载产品说明书 产品说明书 FAQ COA 已发表文献 性能参数 表达区间及表达系统(Source) PE-labeled Human HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer Protein is expressed from HEK293 with His tag and Avi tag at the C-Ter...