The immune function and immune cell scores of the high-risk group were generally higher than those of the low-risk group.CONCLUSION Pyroptosis-related genes play a significant role in tumor immune microenvironment. This novel model, which contains 5 pyroptosis-related genes, is an independent ...
Lung adenocarcinoma (LUAD) remains the most common deadly disease and has a poor prognosis. Pyroptosis could regulate tumour cell proliferation, invasion, and metastasis, thereby affecting the prognosis of cancer patients. However, the role of pyroptosis-related genes (PRGs) in LUAD remains unclear....
such as computer science, statistics, and biology. Previous studies have used bioinformatics to identify potential genes involved in the pathogenesis of infantile hemangiomas.Citation11–13In this study, we used various bioinformatic
In the current study, we performed bioinformatics analysis to determine the expression profiles of pyroptosis-related genes between normal kidney and DN tissues, and identified two types of DN subgroups according to pyroptosis-related genes. And we found that these two patterns have different immune ...
Xing and Li BMC Bioinformatics (2022) 23:177 https://doi.org/10.1186/s12859-022-04726-7 BMC Bioinformatics RESEARCH Diagnostic and prognostic values of pyroptosis‑related genes for the hepatocellular carcinoma Mindan Xing1 and Jia Li1,2* Open Access *Correspondence: ...
Figure 7Protein–protein interaction (PPI) network. (A) PPI network of IH-associated pyroptosis-related genes (IH-PRGs) constructed with the STRING database. Each network node represents a protein, and the lines represent protein–protein associations. (B) Visualization produced in R software of ...
Besides, potential signature genes were selected by machine learning (ML) algorithms, and then validated by testing datasets which included samples of colonic mucosal tissue and peripheral blood. More importantly, the potential drug was screened based on this. And these signature ...
The homeostasis of the epidermis depends on keratinocyte differentiation and cornification, a mode of programmed cell death that does not elicit inflammation. Here, we report that cornification is associated with the expression of specific genes that control multiple steps of pyroptosis, another form ...
We analyzed the risk factors affecting the prognosis of patients and constructed a nomogram to predict the overall survival of patients based on different pyroptosis-related genes (PRGs) subtypes. Methods The genomic data of LUAD were downloaded from the TCGA and GEO databases, and all data were...
chinensis, and pyroptosis-related genes. Toll-like receptor (TLR) and peroxisome proliferator-activated receptor (PPAR) signaling pathways were linked to candidate genes. Additionally, immune cell infiltration analysis revealed that CASP8 was associated with natural killer T cells, natural killer cells,...