However, the role of pyroptosis-related genes (PRGs) in LUAD remains unclear. In our study, comprehensive bioinformatics analysis was performed to construct a prognostic gene model and ceRNA network. The correlations between PRGs and tumour-immune infiltration, tumour mutation burden, and ...
Expression of the pyroptosis-related genes (PRGs) in osteosarcoma.AThe heatmap showed the expression levels of 57 PRGs in normal and tumor samples.BThe boxplot of 23 differentially expressed PRGs (logFC > 1) between the normal and the tumor tissues Full size image Establishment and evaluati...
The differentially expressed genes (DEGs) will be integrated with the pyroptosis-related genes (PRGs) to identify the PRGs network involved in the differential expression of SCI. This approach will enhance our understanding of the role of PRGs in SCI and help to elucidate the specific mechanisms ...
However, the role of pyroptosis-related genes (PRGs) in MM remains undetermined. The aims of this study were to identify potential prognostic biomarkers and to construct a predictive model related to PRGs. Methods Sequencing and clinical data were obtained from The Cancer Genome Atlas (TCGA) and...
Construction of a neuroblastoma (NB) prognostic predictive model based on pyroptosis-related genes (PRGs) to improve individualized management of NB patien
The role of pyroptosis-related genes (PRGs) in esophageal adenocarcinoma (EAC) remains unknown. In this study, the first PRGs prognostic signature (PPS) of EAC was constructed based on the results of multivariate stepwise Cox regression analysis. Based o
In this study, we established a prognosis prediction model for LUAD patients based on the pyroptosis-related genes (PRGs), and confirmed the validity and applicability of the model. 13 PRGs-related genes (IL-1A, P2RX1, GSTM2, ESYT3, ZNF682, KCNF1, STK32A, HHIPL2, GDF10, NDC80, GST...
PRGs: Pyroptosis-related genes RNA-seq: RNA-sequencing TCGA: The Cancer Genome Atlas GEO: Gene expression omnibus PPI: Protein–protein interaction STRING: Search Tool for the Retrieval of Interacting Genes GO: Gene ontology BP: Biological process CC: Cellular component MF: Molecular ...
Moreover, as for gynecologic cancer, in vitro and bioinformatics analysis were the main methodology conducting to explore roles of pyroptosis-related genes (PRGs) and formation of inflammasomes in cancer progression and prognosis. Pyroptosis has evolved into a burgeoning research field in oncology. The...
In this research, we systematically analyze the genetic and transcriptional alterations of pyroptosis-related genes (PRGs) in ccRCC, identify pyroptosis-related subtypes, analyze the clinical and microenvironmental differences among different subtypes, develop a corresponding prognostic model to predict the ...