However, the impact of the expression levels of pyroptosis-related genes (PRGs) on the overall survival (OS) of osteosarcoma patients remains unclear. This study aims to investigate the impact of the expression levels of PRGs on the OS of pediatric and young adult patients with osteosar...
Osteosarcoma is a highly malignant tumor, with very high disability and fatality rates. However, the overall prognosis is not optimistic. Pyroptosis is a newly discovered cell death modality accompanied by inflammation, which is closely related to varieties of cancers. In this study, the RNA-seq d...
We found that these pyroptosis-related genes showed significant differential expression in the transcriptome profiles of 360 TNBC tissues versus 88 normal breast tissues, and most of them showed marked upregulation (Fig. 2c). Depicting the transcriptome features of 45 genes in a relational map ...
Construction of a neuroblastoma (NB) prognostic predictive model based on pyroptosis-related genes (PRGs) to improve individualized management of NB patien
Multiple myeloma (MM) is an incurable and relapse-prone disease with apparently prognostic heterogeneity. At present, the risk stratification of myeloma is still incomplete. Pyroptosis, a type of programmed cell death, has been shown to regulate tumor gr
A protein–protein interaction (PPI) network was used to select hub genes and DGIdb database was utilized to screen potential therapeutic drugs/compounds targeting hub genes. Results A total of 24 differentially expressed pyroptosis-related genes were identified in DN. A 16 gene predictive model ...
We found that these pyroptosis-related genes showed significant differential expression in the transcriptome profiles of 360 TNBC tissues versus 88 normal breast tissues, and most of them showed marked upregulation (Fig. 2c). Depicting the transcriptome features of 45 genes in a relational map ...
The differentially expressed genes (DEGs) will be integrated with the pyroptosis-related genes (PRGs) to identify the PRGs network involved in the differential expression of SCI. This approach will enhance our understanding of the role of PRGs in SCI and help to elucidate the specific mechanisms ...
Characterization of pyroptosis-related genes at the biological level in tumor. A The heatmap revealed that expression levels of 35 of 52 PRGs in tumor and normal tissues were imbalanced, with red representing high expression and blue representing low expression (Wilcoxon test, *P < 0.05; **P...
77 Moreover, other signatures based on pyroptosis-related lncRNAs are also associated with prognosis and the TME in lung cancer.78 In addition to lncRNAs, multiple models based on pyroptosis-related genes are related to survival and inflamed immunotypes in lung cancer.79, 80, 81, 82, 83, 84...