Kumar V, Kaur K, Gupta GK, Sharma AK (2013a) Pyrazole containing natural products: synthetic preview and biological significance. Eur J Med Chem 69:735–753Kumar V, Kaur K, Gupta GK, Sharma AK (2013b) Pyrazole containing natural products: synthetic preview and biological significance. Eur J...
Scheme 1. Pyrazole atom numbering and pyrazole-containing drugs and natural products. Read more View article Overview of recent developments of pyrazole derivatives as an anticancer agent in different cell line Fatima Ezzahra Bennani, ... My El Abbes Faouzi, in Bioorganic Chemistry, 2020 7 Conclus...
Pyrazoles consist of a doubly unsaturated 5-membered ring containing two nitrogen atoms (1 and 2 positions of the ring) (Scheme 1). Knorr synthesized firstly a pyrazole derived compound in 1883, which led to discovery of antipyrine and its derivatives [1]. Since the introduction of antipyrine...
2.3 Synthesis of both nitrogen and oxygen containing heterocycles using nanoparticles under ultrasonication The chemistry of heterocyclic compounds containing both N- and O-heterocycles is interesting for its theoretical implications, for the multiplicity of its synthetic protocols, and for the biological and...
We presume that the differences in immunoreactivity of the protein end-products containing curcumin and its pyrazole derivatives could be due to different mechanisms of oligomerization in the presence of different compounds. Next the compounds 3, 6 and 15 were evaluated for their ability to modulate ...
No direct relationship was found between chain size and PARP1 inhibitory activity; for example, the compound 8o containing a 3-carbon chain presented an IC50 of 102.00 ± 1.20 nM, the compound 8p with a 5-carbon chain had IC50 of 285.00 ± 3.70 nM while compound 8q with a 6-carbon ...
The pyrazole compound (I) (10 parts) is added to 40 parts of an aqueous solution containing polyvinyl alcohol (6 parts), and the mixture is stirred in a mixer. To the resultant dispersion, 40 parts of an aqueous solution containing xanthane gum (0.05 part) and aluminum magnesium silicate ...
Pyrazole containing natural products: Synthetic preview and biological significance. Eur. J. Med. Chem. 2013, 69, 735–753. [CrossRef] 7. Behr, L.C.; Fusco, R.; Jarboe, C.H. The Chemistry of Heterocyclic Compounds Pyrazoles, Pyrazoline, Pyrazolidines, Indazoles and Condensed Rings; ...
Pyrazole containing natural products: Synthetic preview and biological significance. Eur. J. Med. Chem. 2013, 69, 735–753. [Google Scholar] [CrossRef] [PubMed] Wei, F.; Zhao, B.-X.; Huang, B.; Zhang, L.; Sun, C.-H.; Dong, W.-L.; Shin, D.-S.; Miao, J.-Y. Design, ...
molecules Article Novel Pyrazole-Hydrazone Derivatives Containing an Isoxazole Moiety: Design, Synthesis, and Antiviral Activity Zaibo Yang 1,*, Pei Li 2 and Xiuhai Gan 3 1 School of Chemistry and Chemical Engineering, Qiannan Normal University for Nationalities, Guizhou, Duyun 558000, China 2 ...