Medicinal uses of dihydropyrazolesCompounds having a structure according to Formula (I): are effective in a method of increasing erythropoietin and vascularization of tissue in a subject in need thereof.Ji-In Kim AlmsteadNicholas John IzzoDavid Robert Jones...
GLUCOPYRANOSYLOXYPYRAZOLE DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, MEDICINAL USE THEREOF, AND INTERMEDIATE THEREFOR A glucopyranosyloxypyrazole derivative represented by the following general\nformula (I), a pharmaceutically acceptable salt of the derivative, or a\nprodr... H Shiohara,H Fuji...
To better understand the nature of lazertinib inhibition, we determined crystal structures of lazertinib in complex with both WT and mutant EGFR and compared its binding mode to that of structurally related EGFR TKIs. We observe that lazertinib binds EGFR with a distinctive pyrazole moiety ...
led to inhibition of solid tumor development in mice. Extract treatment significantly reduced tumor cell GSH,γ-glutamyl transpeptidase (GGT) and nitric oxide (NO) levels in the tumor bearing animals. Analysis of the extract revealed presence of 4-pyrrolidinyl, pyrazole, and ketone derivatives [82...
Four series of pyrazole moiety were synthesized and screened for cytotoxicity on different cancer cell lines namely, A549, Hep G2, MCF-7, and PC-3. The compound 134 was tested against VEGFR-2, BRAF, CRAF, c-Met, EGFR, and Flt-3 kinase. Analog 134 shows potent anticancer activity ...
Novel 1,1'-(5,5'-(1,4-phenylene)bis(3-aryl-1H-pyrazole-5,1-(4H,5H)-diyl))diethanones 7-12 were tested for their antimicrobial activity by disc diffusion and twofold serial dilution method against the tested bacterial and fungal strains. Compounds 7 again
Zareifopoulos N, Lagadinou M, Karela A, Kyriakopoulou O, Velissaris D. Neuropsychiatric effects of antiviral drugs. Cureus. 2020;12.https://doi.org/10.7759/cureus.9536. Hamdy NA, El-Senousy WM. Synthesis and antiviral evalution of some novel pyrazoles and pyrazolo [3, 4-d] pyridazines...
Evaluation of anti-malarial potency of new pyrazole-hydrazine coupled to Schiff base derivatives Article Open access 22 August 2022 In silico and in vivo anti-malarial investigation on 1-(heteroaryl)-2-((5-nitroheteroaryl)methylene) hydrazine derivatives Article Open access 29 June 2020 Antipl...
And as the SGLT2 inhibitors, glucopyranosyloxypyrazole derivatives (see Patent reference 4), glucopyranosyloxybenzylbenzene derivatives (see Patent reference 5) and the like are known. Both of the above mentioned SGLT1 inhibitors and SGLT2 inhibitors have a glucopyranosyl group bound to an aryl group...
Different medicinal uses of this plant have been reported in the literature, for example, decoction of the bark of this plant treats internal hemorrhages. The oil extracted from Calophyllum inophyllum seeds is used to treat rheumatoid arthritis or joint disorders; itching; eczema; pimples appearing ...