Moreover, pyrazole containing drugs have approved such as celecoxib, antipyrine, phenylbutazone, rimonabant and dipyrone [37]. The researchers have synthesized and evaluated the biological activity of pyrazole derivatives against viruses. Looking at the recent studies, it was observed that the ...
With wide application in medicine and industry, the pyrazole ring is essential in rational drug development. As a privileged structure present in different classes of drugs, the pyrazole moiety has inspired new classes of drug development. The pyrazole moiety is a nitrogen-containing heterocyclic core...
Current inhibitor drugs may block several pathways simultaneously but cause adverse and side effects. Therefore, we designed novel acyl thiourea derivatives containing pyrazole ring to selectively inhibit a kinase dependent pathway in cancer. In this study, breast and bone cancer cells were employed to...
Synthesis and anticancer activity of some fused heterocyclic compounds containing pyrazole ring. Polycycl Aromat Compd. 2020;40(4):1280–1290. (Open in a new window)Web of Science ®(Open in a new window)Google Scholar Aonofriesei F. Effect of methylpyrazoles and coumarin association on ...
Here in this work, novel pyrazole ring-containing isolongifolanone derivatives were designed, synthesized (Fig. 3) and evaluated for their anti-proliferative activities against three human cancer cell lines in vitro. In addition, we also preliminarily probed the underlying anti-proliferative mechanisms...
Compounds PtPz1, PtPz2, and PtPz3 with methyl substituents at the pyrazole ring showed stronger activity than pyrazole or ethylpyrazole containing complexes. Studies have shown that inhibition of cell survival occurs by arresting the G1 cell cycle and inducing apoptosis. Our analysis associated ...
It can be seen, thatthe compounds 12e, 12f, and 12 k containing a para-bromo attached phenyl group directly bound to the thiazole ring showed the highest inhibitory activity, it may be attributed negative inductive effect of the Cl, Br group enhanced the activity. Also, ...
respectively. Again, the methyl group attached to the 4 position of the same ring observed atδ = 23.75 ppm. When the1H-NMR spectrum of6gwere analyzed which containing sulfisoxazole, the methyl protons bonded to the third and fourth positions of the isoxazole ring appeared as single peaks...
They found that replacing the benzene ring of phenanthridin-6-one (half maximal inhibitory concentration (IC50 = 0.52 µM)) with the pyrazole ring containing a substituted phenyl group (1a) increased the inhibitory activity against PARP1 (IC50 = 0.1 µM), while the isomeric derivative, ...
As used herein the term “carbocyclic” refers to a cyclic ring or ring system whose ring atoms are all carbon, and includes monocyclic aryl, cycloalkyl and cycloalkenyl radicals. As used herein the term “heteroaryl” refers to a mono-, bi- or tri-cyclic aromatic radical containing one ...