SUBSTANCE: invention describes a method of synthesis of pyrazole and its derivatives of the formula (I) where R1,R2 and R3 have values indicated above and hydrazine or its derivatives of the formula (III) H2N-NHR4 (III) where R4 has the above indicated values. Method involves the use of ...
Synthesis and biological studies of some imidazolinone derivatives A Series of 4-(1-Aryl-5-oxo-2-phenyl-2-imidazolin-4-yl) metheno-5-chloro-3-methyl-1-phenyl-3-pyrazole) were synthesised and tested for their antibacterial, antiinflammatory and analagesic activities. Some of the compounds show...
系统标签: pyrazole derivatives biological synthesis evaluation design Design,Synthesis,andBiologicalEvaluationofPyrazoleDerivativesChunqiHu1,YaliGao1andWentingDu2,*1CollegeofChemistryandChemicalEngineering,ShaoxingUniversity,Shaoxing312000,China2DepartmentofPharmacy,ZhejiangMedicalCollege,481BinwenRoad,Hangzhou310053,China...
5-Alkoxy-3-(N-substituted carbamoyl)-1-substituted phenylpyrazoles (VIII) were synthesized from 5-hydroxypyrazole (IV) by alkylation and amidation. The relationship between their structures and biological activities, such as analgesic or antiinflammatory activities, was assayed by the carrageenin foot...
Synthesis and selective antitubercular and antimicrobial inhibitory activity of 1-acetyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives The new compounds 1-aryl-3-{1-phenyl-3-[p-(methylthio)phenyl]pyrazol-4-yl}-2-propen-1-ones 2a–l were prepared by the condensation of 1-phenyl-3-[...
An ecofriendly itinerary for the synthesis of pyranopyrazole derivatives having thioether link has been established via reusable, green catalyst, green solvent and multicomponent domino approach. To avoid impurities, usage of toxic solvents, toxic catalyst, simple workup and quantitative yields were strat...
Enaminonitrile in heterocyclic synthesis: Synthesis and antimicrobial evaluation of some new pyrazole, isoxazole and pyrimidine derivatives incorporating a... Enaminonitrile 2 was used as key intermediate for the synthesis of polyfunctionally substituted heterocycles (e.g. pyrazoles, isoxazole, pyrimidine...
Synthesis of novel pyrazolo[3,4-d]pyridazine, pyrido[1,2-a]benzimidazole, pyrimido[1,2-a]benzimidazole and triazolo[4,3-a]pyrimidine derivatives 4-Acetyl-5-methyl-1-phenyl-1H-pyrazole reacts with dimethylformamide dimethylacetal (DMF-DMA) to afford the corresponding (E)1-(5-methyl-1-phenyl...
A convenient route for the synthesis of new variety of pyrazolo[1,5-a]pyrimidine derivatives by the reaction of 5-aminopyrazoles with suitable unsaturated ... GH Elgemeie,HA Ali - 《Synthetic Communications》 被引量: 43发表: 2002年 Heterocyclic Synthesis via Enaminonitriles: One-pot Synthesis...
Synthesis and antiviral/antitumor activity of some substituted pyrazole and pyrazolo[4,3-d]-1,2,3-triazin-4-one nucleosides Following our recent discovery that 9-beta-D-ribofuranosylpurine-6-carboxamide (1) exhibits potent antiviral activity, we were prompted to synthesize certa... Stefano,...