PTENα and PTENβ (PTENα/β), two long translational variants of phosphatase and tensin homolog on chromosome 10 (PTEN), exert distinct roles from canonical PTEN, including promoting carcinogenesis and accelerating immune-resistant cancer progression. H
PTEN (phosphatase deleted on chromosome 10; also known as MMAC1 or TEP1 (tensin-like phosphatase) is a human tumor suppressor gene mapping onto chromosome 10 at 10q23.3 [5]. The PTEN gene is either deleted or inactivated in several tumors, including those associated with breast, endometrial,...