A microprotein N1DARP encoded by LINC00261 promotes Notch1 intracellular domain (N1ICD) degradation via disrupting USP10-N1ICD interaction to inhibit chemoresistance in Notch1-hyperactivated pancreatic cancer Article Open access 15 September 2023 The proprotein convertase furin is a pro-oncogenic driv...
PTEN (phosphatase deleted on chromosome 10; also known as MMAC1 or TEP1 (tensin-like phosphatase) is a human tumor suppressor gene mapping onto chromosome 10 at 10q23.3 [5]. The PTEN gene is either deleted or inactivated in several tumors, including those associated with breast, endometrial,...