Polydatin(Polydatin,PD)is a di -styrene polyphenols andsingle crystal natural compounds. It is mainly separated from the rhizomes and roots of the tab, which is traditionally used to treat inflammation, infection, jaundice, skin burns, and hyperlipidemia. This chemical also exists in other plant s...
Uveal melanoma (UM) is a rare ocular tumor. The loss of BRCA1-associated protein 1 (BAP1) and the aberrant activation of G protein subunit alpha q (GNAQ)/G protein subunit alpha 11 (GNA11) contribute to the frequent metastasis of UM. Thus far, limited molecular-targeted therapies have b...
Neurons are highly specialised cells with a large bioenergetic demand, and so require a healthy mitochondrial network to function effectively. This network is compromised in many neurological disorders, in which damaged mitochondria accumulate. Dysfunctional mitochondria can be removed via an organelle-speci...
Small-cell lung cancer (SCLC) is a deadly tumour accounting for approximately 15% of lung cancers and is pathologically, molecularly, biologically and clinically very different from other lung cancers. While the majority of tumours express a neuroendocrine programme (integrating neural and endocrine pro...
Inflammatory Bowel Disease (IBD) is a chronic inflammatory disease with relapse and remission periods. Ulcerative colitis and Crohn’s disease are two major forms of the disease. IBD imposes a lot of sufferings on the patient and has many consequences; h
miR-21 has been observed to be involved in regulating tumour progression and acting as a oncomiR by targeting and negatively regulating the PTEN gene, which was one of the first tumour suppressor genes identified [177]. Another miRNA related to the PTEN gene is miR-130a. An in vitro study ...
High-penetrance genes include BRCA1, BRCA2, TP53, PTEN, STK11, CDH1, and PALB2 [120]. To date, BRCA1 and BRCA2 are the most common and widely studied breast cancer susceptibility genes, accounting for up to 40% of familial breast cancer. The BRCA1 gene codes for a nuclear phosphoprot...
PHTS is an autosomal dominant inherited disease resulting from a germline mutation in the PTEN gene. Bannayan-Riley-Ruvalcaba Syndrome in a Case Evaluated Due to Multinodular Goiter At the end of the discharge phase from the primary circuits, taking also into account other heat sources as the ...
While infiltration by macrophages is generally a poor prognostic factor in different types of cancer, in CRC it seems to be associated with a better prognosis[19], suggesting that antitumorigenic properties dominate in vivo. Adaptive immunity A specific antitumor response is generated by the adaptive...
PTEN Phosphatase and TENsin homolog deleted on chromosome 10 PR partial response PROTAC proteolysis-targeted chimeras RAF rapidly accelerated fibrosarcoma RAS rat sarcoma RB retinoblastoma RET rearranged during transfection RR response rate VHL Von Hippel-Lindau Sorry, something went wrong. Please try again...