In the clinic, the PTEN germline mutation cannot be used as the basis for the detection of breast cancer.doi:10.1016/j.gene.2020.144630Yu WuDabing HuangHuanhuan ZhangXiaoling WengZhen HuGene
Phase II Trial of AKT Inhibitor MK-2206 in Patients With Advanced Breast Cancer Who Have Tumors With PIK3CA or AKT Mutations, and/or PTEN Loss/PTEN Mutation. Breast Cancer Res (2019) 21(1):78–12. doi: 10.1186/s1...
PTEN, NEDD4, Breast carcinoma, IHCPTEN is an important tumor suppressor gene that antagonizes the oncogenic PI3K/AKT signaling pathway and has functions in the nucleus for maintaining genome integrity. Although PTEN inactivation by mutation is infrequent in breast cancer, transcript and protein levels...
52 PTEN has been implicated in multiple human malignancies including breast,53 glioblastoma54 and prostate cancer.55 Loss of PTEN function can occur through homozygous gene deletion, point mutation or loss of expression. The human PTEN gene encodes a 403-amino-acid polypeptide with a high degree ...
[KEYWORDS]PTENgene;genemutation;inheritedcancersyndrome [AcadJSecMilMedUniv(2005)26(1):90292] PTEN是迄今为止人们发现的惟一具有双重磷酸酶功能的抑癌基因。体细胞PTEN基因突变与多种散发性恶性肿瘤的发生有关,如神经胶质细胞瘤、肾癌、子宫内膜癌、前列腺癌、乳腺癌等,同时PTEN在鼠和人类的正常发育中起着重要的...
Among 84 breast cancer patients with genetic high risks, the carry mutation rate was 40.5% (34/84) and the pathogenic mutation rate was 15.4 (13/84) . Among 44 sporadic cases, the carry mutation rate was 9% (4/44) . The pathogenic mutation rate was 6.8% (3/44) . Breast cancer ...
20.Li YL, Tian Z, Wu DY, Fu BY, Xin Y. Loss of heterozygosity on 10q23.3 and mutation of tumor suppressor gene PTEN in gastric cancer and precancerous lesions.World J Gastroenterol. 2005;11:285-288.[PubMed] 21.Oki E, Baba H, Tokunaga E, Nakamura T, Ueda N, Futatsugi M, Mash...
A new tumor suppressor gene PTEN/MMAC1 was recently isolated at chromosome 10q23 and found to be inactivated by point mutation or homozygous deletion in glioma, prostate and breast cancer. PTEN/MMAC1 was also identified as the gene predisposing to Cowden disease, an autosomal dominant cancer ...
Genomic aberrations of the PTEN tumour suppressor gene are among the most common in prostate cancer. Inactivation of PTEN by deletion or mutation is identified in ∼20% of primary prostate tumour samples at radical prostatectomy and in as many as 50% of castration-resistant tumours. Loss of ph...
gene mt~ated in htr ra n brain, breast, and p∞ e cancer[J ] Science,1997 ,275(5308 ) :1943—1947 【2]Sceck PA . r5h0use M Jas r .打 Identitlcation cf Ⅱ candidate nJ rD suppremor gene. b~ 4AC 1. at chir rnclsort~ ...