The PTEN gene, which consists of nine exons, is located on chromosome 10q23.3 and encodes a 403-amino acid cytoplasmic protein that contains two domains in the N-terminus, a region with lipid phosphatase activity that dephosphorylates PIP3 to PIP2, and a region that interacts with cellular ...
Gene Symbol PTEN Gene ID (NCBI) 5728 RRID AB_2881415 Conjugate Unconjugated Form Liquid Purification Method Protein A purification UNIPROT ID P60484 Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Storage Conditions Store at -20°C. Stable for one year after shipment. Ali...
Full Namephosphatase and tensin homolog Calculated Molecular Weight47 kDa Observed Molecular Weight55 kDa GenBank Accession NumberBC005821 Gene SymbolPTEN Gene ID (NCBI)5728 RRIDAB_2174343 ConjugateUnconjugated FormLiquid Purification MethodAntigen affinity purification ...
Full Name phosphatase and tensin homolog Calculated Molecular Weight 47 kDa Observed Molecular Weight 55 kDa, 68 kDa GenBank Accession Number BC005821 Gene Symbol PTEN Gene ID (NCBI) 5728 RRID AB_2878977 Conjugate Unconjugated Form Liquid Purification Method Antigen affinity purification UNIPROT ID P6...
Loss-of-function mutations in the PTEN gene are frequent in human cancer3. In addition to phosphatase-inactive mutations, abundant stop-gained mutations were detected in exons encoding the C-terminal domain of PTEN (Fig. 1a). Through induction of PTEN instability, stop-gained mutations restrict ...
7 Nuclear PTEN interacts with centromeres to maintain their stability,8 is involved in DNA repair,9 and regulates gene transcription.10,11,12,13 Mono-ubiquitination of PTEN by Nedd4 and deubiquitination by HAUSP/USP7 contribute to the regulation of the nuclear import and export of PTEN.14,15...
PTEN is one of the most commonly deleted/mutated tumor suppressor genes in human prostate cancer. As a lipid phosphatase and negative regulator of the PI3K/AKT/mTOR pathway, PTEN controls a number of cellular processes, including survival, growth, prolif
Recombinant Human PTEN protein价格:￥1280/支产品详情:PTEN gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The prote... 纯度:>90% 包装规格:50ug 用途:科研实验 货号:CSP00150 品牌:chemstan ...
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PTEN is a tumor suppressor gene with anti-proliferative and apoptotic activity [104,105]. PTEN induces apoptosis via the AKT/PI3K pathway inhibition [106], and its expression is epigenetically silenced in several cancers [107]. There is evidence that the pseudogene PTEN gene 1 (PTENpg1, also...