Recombinant Human PTEN protein价格:￥1280/支产品详情:PTEN gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The prote... 纯度:>90% 包装规格:50ug 用途:科研实验 货号:CSP00150 品牌:chemstan ...
The PTEN gene was first identified and cloned in 1997, and PTEN protein has proved to be a powerful tumour suppressor1,2. It is one of the most frequently mutated or deleted genes in cancer, including cancer of the brain, breast, prostate, pancreas and ovary3. Germline mutations of the ...
The PTEN gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially de...
et al. Pten (phosphatase and tensin homologue gene) haploinsufficiency promotes insulin hypersensitivity. Diabetologia 50, 395–403 (2007). Article PubMed CAS Google Scholar Eguez, L. et al. Full intracellular retention of GLUT4 requires AS160 Rab GTPase activating protein. Cell Metab. 2, 263...
The PTEN gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this ...
The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation.The PTEN/MMAC1 discovers the first to have the suppress of the phosphoric acid enzyme activity cancer gene currently.The gene of PTEN locates the chromosome10q23 area, sending forth sex tumor and a few households cancers ...
Full size image To identify the circular characteristics of cZNF215, Sanger sequencing was performed to identify the back-splice junctions (Fig.1D). cZNF215 is derived from exons 2, 3 and 4 of theZNF215gene, as well as transcript variant 1 (transcript ID: ENST00000278319.10, transcript na...
Full size image And then we would like to further explore the effects of the miR-21 inhibitor and taxol on the key members of the AKT pathway. Overexpression of the gene encoding the epidermal growth factor receptor (EGFR) occurs commonly in glioblastoma, leading to activation of downstream kin...
Full size table Subsequent gene enrichment and pathway analyses (Ingenuity Pathway Analysis [IPA] software) on the transcriptomic data from the cortices of 6-week-oldPtenm3m4/m3m4mice, identified significant enrichment of pathways defined as “activation of myeloid cells”, “phagocytosis”, “cell ...
Loss-of-function mutations in thePTENgene are frequent in human cancer3. In addition to phosphatase-inactive mutations, abundant stop-gained mutations were detected in exons encoding the C-terminal domain of PTEN (Fig.1a). Through induction of PTEN instability, stop-gained mutations restrict the ...