参考文献 1. Campbell ZT, Bhimsaria D, Valley CT, et al. Cooperativity in RNA-protein interactions: global analysis of RNA binding specificity.Cell Rep.1, 570–581 (2012). 2. Pisignano G, Ladomery M. Epigenetic r...
1. **"PTBP1 controls alternative splicing and metabolic switching in cancer"** *作者:Xue Y, et al. (2019)* **摘要**:研究使用PTBP1抗体通过免疫印迹和免疫沉淀技术,揭示了PTBP1在肿瘤代谢重编程中的作用,证明其通过调控选择性剪接促进癌细胞糖酵解。 2. **"The RNA-binding protein PTBP1 is neces...
1.Campbell ZT, Bhimsaria D, Valley CT, et al. Cooperativity in RNA-protein interactions: global analysis of RNA binding specificity. Cell Rep. 1, 570–581 (2012). 2.Pisignano G, Ladomery M. Epigenetic regulation of alternative splicing: how lncRNAs tailor the message. Noncoding RNA 7, ...
SARS-CoV-2 neurotropism has been increasingly recognized by its imaging and syndromic manifestations in the literature. The purpose of this report is to explore the limited yet salient current evidence that SARS-CoV-2's host genomic targets PTBP1 and the 14-3-3 protein isoform encoding genes ...
catRAPID omics v2.0: going deeper and wider in the prediction of protein-RNA interactions. Nucleic Acids Res. 2021;49:W72–W9. Article CAS Google Scholar Zhu Y, Xu G, Yang Y, Xu Z, Chen X, Shi B, et al. POSTAR2: deciphering the post-transcriptional regulatory logics. Nucleic ...
Gastric cancer (GC) tumorigenesis and treatment failure are caused by cancer stem cells. Polypyrimidine tract binding protein 1 (PTBP1) was shown to be involved in the development of embryonic stem cells and is now being considered as a therapeutic targe
Here, we report that two well-characterized splicing factors, polypyrimidine tract-binding protein 1 (PTBP1) and polypyrimidine tract-binding protein 2 (PTBP2), are also nonconserved cryptic exon repressors. In contrast to TDP-43, PTBP1 and PTBP2 utilize CU microsatellites to repress both ...
Nuclear RBPs mainly process precursor mRNAs, including RNA modifications and alternative splicing. Moreover, cytoplasmic RBPs mainly regulate mRNA transport, controlling mRNA stability and interactions with the translational machinery [9]. Recently, more studies have indicated that RBPs participate in the...
The alternative splicing of the pyruvate kinase M (PKM) gene regulates the expressions of PKM1/2 isoforms and the aerobic glycolysis of tumors. Polypyrimidine tract binding protein (PTBP1) is critical in this process; however, its impact and underlying mechanisms in colorectal cancer (CRC) remain...
The schematic shows the effect of circSCP2 on CRC cells through sponging miR-92a-1-5p and also suppressing PTBP1 degradation, and subsequently promote EMT, tumor migration and invasion via upregulation of downstream IGF2BP1 mRNA and protein expression. Moreover, exosomal circSCP2 released by ...