The ontogeny of these Foxp3 Tregs - selective accumulation or proliferation of natural thymus-derived Treg (nTreg) or induced Treg (iTreg) converted in the periphery from nave T cells - is not known. We used several strains of mice in which Foxp3 and EGFP are coordinately expressed to ...
常规t细胞(也称为tconv或teff)具有效应功能(例如细胞因子分泌、细胞毒性活性、抗自我识别等)以借助于表达一种或多种t细胞受体来增加免疫反应。tconv或teff通常定义为任何非treg的t细胞群体并包括例如初始t细胞、活化t细胞、记忆t细胞、静息tconv或分化成例如th1或th2谱系的tconv。在一些实施方案中,teff是非调控性t细胞(...
(B)破裂的肿瘤内高频率的PSGL-1+,PD-1+(双重阳性)CD4+非Treg(效应T细胞)和Treg,通过流式细胞术进行。 图24显示黑素瘤中免疫细胞的存在,和它们的PSGL-1表达。(A)黑素瘤肿瘤内鉴定的T细胞(CD4+非Treg,Treg,CD8+细胞),NK T细胞,NK细胞,树突细胞(DC,MHC II+,CD11c),髓样衍生抑制细胞(MDSC,Gr1+,CD11b)...
No differences in T regulatory (Treg) cell frequencies, numbers, or capacity to inhibit proliferation of WT T cells were found (data not shown), and Selplg−/− mice had a normal lifespan. We did not find differences in the serum concentrations of the pro-inflammatory cytokines IL-6, ...
BackgroundPrevious studies in our lab have established that PSGL-1 signaling in human monocyte-derived dendritic (DC) cells induces a tolerogenic program that enables them to promote the differentiation of na茂ve T cells to T regulatory cells (Treg). We have also found that PSGL-1 modulates ...
在一个方面,该psgl-1调控剂是抗体,小分子,蛋白质,融合蛋白或核酸。在一个具体方面,该抗体是单克隆抗体,嵌合抗体,人抗体或人源化抗体。在另一个方面,cd4+依赖性cd8+ t细胞应答升高。在一个另外的方面,病毒特异性t细胞升高。在另一个方面,treg和 dc应答升高。在又一个方面,foxp3,il-10,tgf-β和/或ii类...