Role of P-selectin glycoprotein ligand-1 (PSGL-1) in DSS colitis-induced recruitment of platelets and T-lymphocytesABSTRACTdoi:10.1016/S0016-5085(03)82471-XMori, MikijiSalter, James W.Vowinkel, ThorstenGranger, Daniel N.Elsevier Inc.Gastroenterology...
8周龄)被随机分成五组(每组5只),称重并标记不同组别小鼠,置于12小时的光/暗循环环境中,并被允许随意获取标准食物和水。给予小鼠2%的dss水溶液7天,随后给予1%的dss水溶液10天,再给予2%的dss水溶液7天,对照组小鼠饮用正常水。 [0121] 从dss给药的第一天开始,每三天记录一次疾病活动指数(dai):包括动物的体重、...
Disease activity index (DAI), histology, and myeloperoxidase (MPO) levels were compared with sham-treated DSS controls. We found that 2PH1 reduced the number of rolling leukocytes (148.7 +/- 29.8 vs. 36.9 +/- 8.7/0.01 mm(2)/30 s, P < 0.05), whereas leukocyte velocity was increased (...
underlying mechanisms.Methods: The interaction of platelets with macrophages was assessed in the presence or absence of the indicated compounds in symbolscript An azoxymethane/dextran sodium sulfate (AOM/DSS)-induced CRC mouse model was used to investigate the role of platelets in controlling CRC ...