The difference in the affinity for the different tRNA species is not reflected in the specific activity of the enzyme, indicating that the binding of Pus1 to tRNA is not the kinetically limiting step. The importance of tertiary base-pairs was investigated with several variants of yeast tRNAs. ...
It is formed when uridine in RNA undergoes site-specific isomerization by a pseudouridine synthase enzyme. Pseudouridine is found in tRNAs from bacteria, archaea, and eukaryotes. In vitro, it reduces the number of X-ray-induced chromosomal aberrations in human lymphocytes isolated from whole blood...
Pseudouridine synthases are responsible for the formation of Ψ in RNA in either a site-specific or snoRNA guide RNA-dependent manner. Pseudouridine synthase 1 (Pus1p) is a member of the TruA family18,19and members of this family and all other pseudouridine synthases, have a conserved aspart...
Genome-wide identification, characterization, and expression analysis unveil the roles of pseudouridine synthase (PUS) family proteins in rice development and stress response Physiol. Mol. Biol. Plants, 29 (2023), pp. 1981-2004 Google Scholar [26] D.Y. Shi, B.C. Wang, H.Y. Li, Y. Lian...
Cancer is one of the major diseases threatening human life and health worldwide. Epigenetic modification refers to heritable changes in the genetic material without any changes in the nucleic acid sequence and results in heritable phenotypic changes. Epi