Mitochondrial myopathy and sideroblastic anemia (MLASA): missense mutation in the pseudouridine synthase 1 (PUS1) gene is associated with the loss of tRNA pseudouridylation. J. Biol. Chem. 280, 19823–19828 (2005). CAS PubMed Google Scholar Mangum, J. E. et al. Pseudouridine synthase 1...
中文名称: 中文同义词: 英文名称: mitochondrial tRNA pseudouridine27/28 synthase 英文同义词: mitochondrial tRNA pseudouridine27/28 synthase CAS号: 分子式: 分子量: 0 EINECS号: 信息错误报告 您的Email: 按国家浏览mitochondrial tRNA pseudouridine27/28 synthase国外供应商 中国供应商美国...
A previous study documented that pseudouridylation synthase 7 (PUS7)-induced production of pseudouridine (Ψ) directed specific 5’tRFs to repress translation in stem cells [87]. These 5’tRFs were derived from tRNA-Ala, tRNA-Cys, and tRNA-Val and carried the TOG sequence at the 5’ end...
Stand-alone pseudouridine synthases have broad range of activity, lack of which leads to reduced growth in yeast cells and major human diseases such as mitochondrial myopathy, sideroblastic anemia (MLASA), or intellectual disabilities [50,51]. The KEOPS complex The bases in position 37 are ...
tRNA-derived fragments (tRFs) are an emerging category of small non-coding RNAs that are generated from cleavage of mature tRNAs or tRNA precursors. The advance in high-throughput sequencing has contributed to the identification of increasing number of t
[19,20]. It has been demonstrated that pseudouridine synthase 7 (PUS7) could activate 5’tRFs, and the inactivation of PUS7 impaired 5’tRFs’ ability to mediate translation and damage to hematopoietic stem cells, which contributes to myelodysplastic syndrome (MDS) [21]. Similarly, 5’-tiRNA...
Since the 1950s, when pseudouridine was identified in RNA molecules (Cohn1951), RNA modification has been known recognized as a conserved phenomenon across all life kingdoms, with important yet enigmatic functions. Transfer RNAs (tRNAs) are a category of small non-coding RNAs with a ‘cloverleaf...
22. Certain tRNA modifications are found only in a single tRNA species, whereas others are found in multiple tRNA species20,23. For example, 2-lysidine (k2C) tRNA modifications are placed at position 34 of the anticodon of tRNAIle(AUA)24, whereas pseudouridine (Ψ) can be placed at ...
A dual-specificity pseudouridine synthase: an Escherichia coli synthase purified and cloned on the basis of its specificity for psi 746 in 23S RNA is also specific for psi 32 in tRNA(phe). RNA 1, 437–448 (1995). CAS PubMed PubMed Central Google Scholar Takakura, M., Ishiguro, K.,...
nuclear and mitochondrial tRFs are positively correlated with shorter genes with high density of repeats, and negatively correlated with longer genes with low density of repeats in most of the 32 cancer types [43]. Third, tRF-mRNA correlations are cancer-specific while uncovering several pathways ...