From The Cancer Genome Atlas (TCGA) cohort, digital whole slide images identified cancers having NP served as label and an information theory algorithm was applied to find which mRNA gene best explained NP. Dyskerin Pseudouridine Synthase 1 (DKC1) was identified.DKC1expression was assessed using ...
Dyskerin pseudouridine synthase 1 ( DKC1 ) is a conserved gene encoding the RNA‐binding protein dyskerin, which is an essential component of the telomerase holoenzyme. DKC1 up‐regulation is frequently observed in many different human cancers including hepatocellular carcinoma (HCC); however, its ...
DKC1;CBF5;DKC;DKCX;NAP57;NOLA4;XAP101;dyskerin pseudouridine synthase 1;H/ACA ribonucleoprotein complex subunit DKC1;CBF5 homolog;H/ACA ribonucleoprotein complex subunit 4;dyskeratosis congenita 1, dyskerin;nopp140-associated protein of 57 kDa;nucleolar protein NAP57;nucleolar protein family A mem...
Dyskerin is a pseudouridine (蠄) synthase involved in fundamental cellular processes including uridine modification in rRNA and small nuclear RNA and telomere stabilization. Dyskerin functions are altered in X-linked dyskeratosis congenita (X-DC) and cancer. Dyskerin's role in rRNA pseudouridylation ...
pseudouridylated RNAs was significantly higher than expected in dyskerin immunoprecipated transcripts (114/701, 16.3 % vs 4128/87,935, 4.7 %—p<0.00008; Additional file1: Fig. S4D). We then performed a bioinformatic analysis of the sequences flanking these 114 known pseudouridines using snoG...
Mutations in DKC1, encoding for dyskerin, a pseudouridine synthase that modifies rRNA and regulates telomerase activity, are associated with ribosomal dysf... C Bellodi,O Krasnykh,N Haynes,... - 《Cancer Research》 被引量: 179发表: 2010年 ...
Sequence Similarities: Belongs to the pseudouridine synthase TruB family. Cellular Location: Nucleus > Nucleolus. Nucleus > Cajal body.Also localized to Cajal bodies (coiled bodies). Database Links: Entrez Gene: 1736 Human Entrez Gene: 245474 Mouse Entrez Gene: 170944 Rat Omim: 300126 Human Swiss...