邻近连接分析,英文Proximity ligation assay,简称PLA, 中文翻译为邻位连接分析或者邻近连接分析技术。 邻近连接分析PLA是一种特殊的免疫分析方法,可用于检测目标蛋白,蛋白相互作用等等。 邻近连接分析PLA由Fredriksson等人于2002年开发。到目前为止,它已成为一种成熟且普遍适用的免疫组化工具,用于高级和精确的蛋白质分析。
location in tissue samples offers exciting new opportunities in biomarker research. By providing the element of dual recognition to in situ analyses, pathology can expand into a new arena of analytes, beyond measuring the abundance of just a single protein.PLA™, a proximity ligation assay ...
allowingdigitalquantificationandinformationabouttheexactlocalizationofthetarget.ARevolutionintheDetectionofProteinsDuolink™enablesresearcherstostudysignallingpathwaysinnativecellsandtissueinrevolutionizingways.BasedonOlinkBioscience’sproprietaryinsituProximityLigationAssay(insituPLA),Duolink™makesitpossibletovisualize,...
Proximity Ligation Assay (PLA)简介 Proximity Ligation Assay (PLA)简介 1, 什么是PLA技术?PLA技术全称为Proximity Ligation Assay， 国内翻译为邻位连接或者邻近连接技术。PLA技术是一种特殊的免疫分析方法，可用于检测目标蛋白，蛋白相互作用等等。 该方法通过一对标记有一段寡聚脱氧核苷酸(单链DNA)的单克隆或者多...
The proximity ligation assay (PLA) is a technique used to examine protein-protein interactions in situ. PLA offers many advantages over traditional biochemical approaches to signaling in that it can detect both transient interactions, which are hard to capture otherwise, as well as protein ...
全称为Proximity Ligation Assay 是一种特殊的免疫分析方法,可用于检测目标蛋白,蛋白相互作用等等。该方法通过一对标记有一段寡聚脱氧核苷酸(单链DNA)的单克隆或者多克隆抗体的探针,即PLA probe(探针),识别目的蛋白,当这两个探针识别同一个蛋白时,两个探针之间的距离靠近,产生了所谓的邻近效应(proximity)。
Optimization of proximity ligation assay (PLA) for detection of protein interactions and fusion proteins in non-adherent cells: application to pre-B ... L Debaize,H Jakobczyk,Anne-Galle Rio,... - 《Molecular Cytogenetics》 被引量: 1发表: 2017年 The interaction between carcinoembryonic antigen...
Proximity ligation assayProximity ligation assayThe present invention relates to compositions and methods for sensitive, rapid and convenient assays to detect and/or quantify one or more target cell or tissue using ribonucleic acid as probes, wherein the method includes binding a first and a second ...
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