we designed two CLDN-5-based membrane protein antigens. First, human/mouse chimeric CLDN-5 (Antigen1, Fig.2a) was constructed. The ECR of mouse CLDN-5, consisting of two extracellular loops and extracellular-side of TMDs, was substituted with corresponding region of human CLDN-5 amino aci...
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albicans enolase, which belongs to the cytosolic proteins identified abundantly on the fungal cell surface [74], and for which a function of an immunodominant antigen detected during systemic fungal infections was also designed [75]. An increased exposition of enolase on the fungal cells contacting ...
Since this early foundational work, these techniques have gained a lot of attention and been applied to biomolecular detection, such as cytokines, cell surface proteins and antigens from viruses and bacteria3,4,5,6,7. The next great leap forward of immuno-PCR happened 10 years after it was ...
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the advantages are that multiple parameters can be analyzed at once and objective data obtained about each parameter. Information aboutcell sizeand granularity and the levels of expression of different antigens have prognostic significance.46-48Becauseformalinfixation damages proteins, most of thecell sur...
including what seems to be an antibody–antigen complex in Fig.2a(centre-right); note that the closest Protein Data Bank (PDB) structural matches to the two ‘antigen’ chains of this complex are at template-modelling (TM) scores41of 0.46 and 0.43, indicating that this sample is not a re...
Virus-coded cell surface antigens that appear soon after the infection of a cell by virus, but before virus replication has begun. Encoded by the so-called early genes. early gene See early antigens. early growth response genes A family of cys2-his2-type zinc-finger proteins; transcription...
Nanobodies are single-domain antibodies that initiate critical immune reactions by interacting with antigens24, where these targets represent three typical interaction modes of nanobodies with the same mouse 2',3'-Cyclic-nucleotide 3'-phosphodiesterase. As shown in Supplementary Fig. 7, the complex ...
2A), automatic detection of multiple antigens in this high-throughput manner (Fig. 2B) has the potential to dramatically shorten turnaround time, reduce the cost of labor and instrument, and eliminate the need of manual handling and subjective interpretation of the WB or IB test results. All ...