CD8 is a glycoprotein present on approximately one-third of T cells in lieu of CD4. Similar to CD4, it binds to a monomorphic region MHC, although it binds to class I rather than to class II antigens. CD8 defines cytotoxic effector cells and perhaps subsets of natural killer and regulatory...
Generation of antigen-specific paired heavy-light chain antibody sequences using large language models [bioRxiv 2024.12.20.629482] • [Supplementary] Learning to engineer protein flexibility [arXiv:2412.18275] • [code] 0) Benchmarks and datasets Sequence dataset/benchmarks • Structure dat...
F. et al. Engineering N-linked protein glycosylation with diverse O antigen lipopolysaccharide structures in Escherichia coli. Proc. Natl Acad. Sci. USA 102, 3016–3021 (2005). Article CAS PubMed PubMed Central Google Scholar Cain, J. A. et al. Proteomics reveals multiple phenotypes ...
P. S. Prediction of continuous B-cell epitopes in an antigen using recurrent neural network. Proteins: Struct., Funct., Bioinforma. 65, 40–48 (2006). Article CAS Google Scholar Gligorijević, V. et al. Structure-based protein function prediction using graph convolutional networks. Nat. ...
Virus-coded cell surface antigens that appear soon after the infection of a cell by virus, but before virus replication has begun. Encoded by the so-called early genes. early gene See early antigens. early growth response genes A family of cys2-his2-type zinc-finger proteins; transcription...
among the eight AD causal genes with either sex-biased expression or genetic regulation of protein expression that we identified, half of them are involved in immune function:CD2APfacilitates recognition of antigen by T cells42;SLMAPparticipates in T cell receptor signaling43;ADAM10regulates cytokine ...
Their activation requires not only the direct stimulation of foreign antigens, but also the co-stimulus signal transmitted by the interaction of surface molecules.148 The CD40/CD40L pathway is one of the most important co-stimulating pathways in T-cell activation. Because of its critical role in...
and membrane receptors. Miyata et al. have pioneered the development of antigen-responsive polymer hydrogels based on competitive antibody–antigen recognition between the target and the corresponding antibody–antigen pair23. The recognition-based mechanism was recently extended to other recognition pairs,...
Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression. Nat Immunol. 2019;20:835–51. Article CAS PubMed PubMed Central Google Scholar Saddic LA, West LE, Aslanian A, Yates JR 3rd, Rubin SM, Gozani O, et al. Methylation of the retinoblastoma tumor ...
(Fig.2c). Although high structural integrity of the CLDN-5 ECR cannot be expected, Antigen2 without the CLDN-5 intracellular region theoretically induces the production of ECR-binding antibodies only. Both antigens induced immune responses with a high rate of success (Table1), and produced ...