GlcNAcylation is linked and involved in regulating the phase separation process (Fig.2). In 2022, Lv P et al. demonstrated through extensive experimental data that T1306 O-GlcNAc of SynGAP prevents the formation of hydrogen bonds with PSD-95, disrupts protein interactions, and thus inhibits LLP...
O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway. Mol Cell. 2014;54:820–31. Article CAS PubMed PubMed Central Google Scholar Rao X, Duan X, Mao W, Li X, Li Z, Li Q, et al. O-GlcNAcylation of G6PD promotes the pentose ...
To date, a sole O-GlcNAc transferase, OGT10, has been shown to catalyze intracellular O-GlcNAcylation11,12. Here we show that O-GlcNAc is expressed in the apical extra- cellular matrix (aECM) and that it is required for epithelial cell adhesion/interaction with the ECM in Drosophila. This...
606 and Ser-669 by PHK. Phosphorylation at Ser-214 by SGK1 mediates microtubule depolymerization and neurite formation in hippocampal neurons. There is a reciprocal down-regulation of phosphorylation and O-GlcNAcylation. Phosphorylation on Ser-717 completely abolishes the O-GlcNAcylation on this site, ...
O-GlcNAcylation can modulate tau phosphorylation with OGA inhibition decreasing phosphorylation [184] preventing tau aggregation and attenuating cognitive decline in double transgenic TAPP mice [185] suggesting that OGA inhibition may be a potential target for AD and other tauopathies; while two ...
In axons, hnRNP R is a component of translation initiation complexes and, through interaction with O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (Ogt), modulates O-GlcNAcylation of eIF4G. Restoring axonal O-GlcNAc levels rescued local protein synthesis and axon growth defects of hnRNP R...
The intersections between O-GlcNAcylation and phosphorylation: implications for multiple signaling pathways. J Cell Sci. 2010;123(Pt 1):13–22. Article CAS PubMed Google Scholar Hu P, Shimoji S, Hart GW. Site-specific interplay between O-GlcNAcylation and phosphorylation in cellular regulation. ...
Stress-induced expression of the p75 neurotrophin receptor is regulated by O-GlcNAcylation of the Sp1 transcription factor. J Neurochem 2011; 116: 396–405. 39. Ramos A, Ho WC, Forte S, Dickson K, Boutilier J, Favell K et al. Hypo-osmolar stress induces p75NTR expression by activating ...
(Fig.1A). Sialic acids are attached to both O- and N-linked glycans (Fig.1B) either at their galactose (Gal) or N-acetylgalactosamine (GalNAc) units via α-2,3- or α-2,6-bonds, or to other sialic acid moieties via α-2,8- or α-2,9-bonds (Table1) by specific enzymes (...
(Vella et al.,2013). Furthermore, Deplus and colleagues showed that TET2 and OGT co-localize at active promoters marked by H3K4me3 through a direct interaction with host-cell factor 1 (HCF1) and that knockdown ofTET2leads to global decreases of H3K4me3 and GlcNAcylation (Deplus et al.,...