Species of Neisseria express broad-spectrum O-linked protein glycosylation where the glycoproteins are largely transmembrane proteins or lipoproteins localized on the cell surface or in the periplasm. There are diverse functions among the identified glycoproteins, for example type IV bioge...
D. Prolonged incubation in PUGNAc results in increased protein O-linked glycosylation and insulin resistance in rat skeletal muscle. Diabetes 53, 921–930 (2004). Article CAS PubMed Google Scholar Wang, X. et al. O-GlcNAcase deficiency suppresses skeletal myogenesis and insulin sensitivity in ...
enzyme sensitivity, and function. In addition, O-linked glycosylation affects protein secretion, immune responses, and cell-to-cell interactions. In some cases, O-linked glycosylation has also been implicated in the development of diseases such as inflammatory bowel disease and cancer....
Specific O-GlcNAc modification at Ser-615 modulates eNOS function. Redox Biol. 2020;36:101625. Article CAS Google Scholar Ednie AR, Bennett ES. Intracellular O-linked glycosylation directly regulates cardiomyocyte L-type Ca2+ channel activity and excitation-contraction cou- pling. Basic Res Cardiol...
糖基的链接分为两种:① N-连接的糖基化(N-linked glycosylation):与天冬酰胺残基的NH₂连接,连接的糖为N-乙酰葡糖胺;② O-连接的糖基化(O-linked glycosylation):与Ser、Thr和Hyp的OH连接,连接的糖为半乳糖或N-乙酰半乳糖胺,在高尔基体上进行O-连接的糖基化。
Pattern analysis and prediction of O-linked glycosylation sites in protein by principal component subspace analysis. In: Apolloni, B., Howlett, R., Jain... Chen,YW,Yang,... - Knowledge-based Intelligent Information & Engineering Systems Pt2: Kes -wirn Lecture Notes in Artificial Intelligence ...
Protein O-linked N-acetylglucosamine (O-... Belke,D D. - 《Journal of Applied Physiology》 被引量: 133发表: 2011年 dbOGAP - An Integrated Bioinformatics Resource for Protein O-GlcNAcylation Background Protein O-GlcNAcylation (or O-GlcNAc-ylation) is an O-linked glycosylation involving the ...
HexNac+Hex C14O10NH23 365.3 182.6 121.8 91.3 73.1 Example ESI Mass Spectrum Above is a sample electrospray mass spectrum showing peaks that differ by 54 amu this is typical of a glycopeptide displaying mannose type glycosylation heterogeneity at the [M+3H]3+ charge state (see the chart above...
IGFBP-6, an O-linked glycoprotein, preferentially binds IGF-II and inhibits its actions. The aim of this study was to investigate whether O-glycosylation modulates the pharmacokinetics of IGFBP-6.The pharmacokinetic profiles of (125)I-labelled glycosylated (g) and non-glycosylated (n-g) ...
Insights into type IV pilus biogenesis and dynamics from genetic analysis of a C-terminally tagged pilin: a role for O-linked glycosylation. Mol. Microbiol. 85, 1166–1178 (2012). Article CAS PubMed Google Scholar Sankaran, K. & Wu, H. C. Lipid modification of bacterial prolipoprotein....