近日,中国农业科学院植物保护研究所粮食作物真菌病害监测与防控团队在《New Phytologist》在线发表题为“Effector secretion and stability in the maize anthracnose pathogenColletotrichum graminicolarequires N-linked protein glycosylation and the ER chaperone pathway”的论文。该论文发现N-糖基化修饰通过维持内质网伴侣蛋...
The oligosaccharide substrate for the N-linked protein glycosylation is assembled at the membrane of the endoplasmic reticulum. Dolichyl pyrophosphate serves as a carrier in this biosynthetic pathway. In this review, we discuss the function of the lipid carrier dolichol in oligosaccharide assembly and ...
N-linkedGlycosylation AlleukaryoticcellsproduceN-glycans.N-linkedglycosylationisthebestunderstoodroutetoproteinglycosylation.ThemolecularcloningofvertebrateglycosyltransferasesandglycosidasegenesinvolvedinN-glycanbiosynthesisbeganinthe1980sandcontinuestothepresent.2.1DiverseN-linkedglycanshaveacommoncorestructure N-乙酰葡糖胺...
N-linked glycosylation is one of the most abundant modifications of proteins in eukaryotic organisms. In the central reaction of the pathway, oligosacchary... E Mohorko,R Glockshuber,M Aebi - 《Journal of Inherited Metabolic Disease》 被引量: 206发表: 2011年 N-Linked Protein Glycosylation in...
This ER-localized pathway results in a systemic modification of the proteome, the basis for the Golgi-catalyzed modification of the N-linked glycans, generating the large diversity of N-glycoproteome in eukaryotic cells. This article focuses on the processes in the ER. Based on the highly ...
N-连接糖基化(N-linked glycosylation) 是一种新生肽链的共翻译或翻译后修饰方式,糖链通过与新生肽链中特定天冬酰胺(N-X-S/T,X≠P)的自由-NH2基连接,所以将这种糖基化称为 N-连接的糖基化。N-糖基化的过程在内质网和高尔基体中进行。N-糖基化修饰主要...
Structures of PD-L1/PD-1 and N-linked glycosylated PD-L1/PD-1. PD-L1, which is a membrane protein that is highly expressed on tumor cells, possesses four asparagine residues that are undergo N-linked glycosylation (N35, N192, N200, and N219) and are distributed across the IgV-like and...
www.nature.com/scientificreports OPEN N-linked glycosylation at Asn152 on CD147 affects protein folding and stability: promoting tumour received: 05 March 2016 accepted: 19 September 2016 Published: 21 November 2016 metastasis in hepatocellular carcinoma Jiang-Hua Li*, Wan Huang*, Peng Lin*...
As a major site of protein biosynthesis, homeostasis of the endoplasmic reticulum is critical for cell viability. Asparagine linked glycosylation of newly synthesized proteins by the oligosaccharyltransferase plays a central role in ER homeostasis due to the use of protein-linked oligosaccharides as rec...
Certain mammalian glycosyltransferases from the N-linked glycosylation pathway have been purified and characterized. The enzymatic machinery for the glycosylation of proteins in mammalian cells is generally located in the membranes of the Golgi apparatus. α(1,3) mannoside β(1,2) UDP-N-acetylglucosam...