The cysteine proteinase legumain is overexpressed in many solid human tumors, and overexpression is associated with enhanced metastasis. Currently, the knowledge about subcellular localization, trafficking and requirements for legumain activation remains largely unexplored. Known factors that influence the ...
Similarly to faeces, for surveillance efforts in a population, the identification of individuals may not be that relevant; however, it remains important to be aware if there is a risk of contamination of the samples with urine from other cohabitating species than the target one [107]. Finally...
The callback of the dragRowIn event is called with the source id instead of the target id Grid/TreeGrid. Incorrect rendering of header/footer spans Grid/TreeGrid. Canceling editing of a cell in the enabled autoHeight mode doesn't revert the value of a cell to the initial state Grid/...
Bio-Techne’s Simple Western™ platform is ideal for high throughput glycan characterization. Download the Simple Western App Note Immunology: C-Terminal Glycosylation Regulates Perforin Activation and Synaptic Toxicity. Cytotoxic T Lymphocytes (CTLs) induce apoptosis in target cells via the activity ...
The backlink from Hubspot is a strong vote of confidence in Backlinko which can improve search rankings for the target URL. But not all backlinks will help with keyword rankings—only high-quality or highly relevant backlinks will move the needle. For example, backlinks can be marked as “...
2). There is 67% sequence identity between the proteins and both the proteins contain the pentraxin (PTX) domain at the carboxyl terminal end, although the rat CRP has an additional N-linked glycosylation at position asparagine 147. Since the actual crystal structure of rat CRP is not known ...
The glycosylation profile of therapeutic antibodies is routinely analyzed throughout development to monitor the impact of process parameters and to ensure consistency, efficacy, and safety for clinical and commercial batches of therapeutic products. In this study, unusually high levels of the mannose-5 ...
The glycosylation profile of therapeutic antibodies is routinely analyzed throughout development to monitor the impact of process parameters and to ensure consistency, efficacy, and safety for clinical and commercial batches of therapeutic products. In this study, unusually high levels of the mannose-5 ...
In addition, N-linked glycosylation, a process during which oligosaccharides are attached to the nitrogen atoms of asparagines in proteins, has been noted as another important post-translational regulation event. N-glycosylation is important for trafficking, stability, activity, and substrate specificity...
The elicitation of broadly neutralizing antibodies (bnAbs) is considered crucial for an effective, preventive HIV-1 vaccine. Led by the discovery of a new generation of potent bnAbs, the field has significantly advanced over the past decade. There is a wealth of knowledge about the development of...