N-linked protein glycosylationWacker, MichaelNew Chemistry & New Opportunities from the Expanding Protein Universe
Protein Glycosylation, Overview N-Linked Glycosylation In eukaryotes, the initiation of N-linkedglycosylationinvolves the synthesis of the core N-linkedoligosaccharide, dolichol-diphosphate-GlcNAc2Man9Glc3, on the cytosolic side of theER membrane. After translocation to the lumen of the ER, the core...
ARTICLE Received 27 Jun 2013 | Accepted 16 Sep 2013 | Published 23 Oct 2013 DOI: 10.1038/ncomms3627 Unexpected reactivity and mechanism of carboxamide activation in bacterial N-linked protein glycosylation Christian Lizak1,*, Sabina Gerber1,*,w, Gae¨lle Michaud2, Mario Schubert1, Yao-Yun Fan...
(2011) Mechanisms and principles of N-linked protein glycosylation. Curr Opin Struct Biol 21, 576-582Schwarz, F. and Aebi, M. (2011) Mechanisms and principles of N-linked protein glycosylation. Curr. Opin. Struct. Biol., 21, 576-582....
N-linked glycosylation-1 Glycobiology Chart2.N-linkedGlycosylation GuLi MajorGlycanClassesinAnimalCells HYALURONANGLYCOSAMINOGLYCANS P CHONDROITINSULFATE SSSSer-O- HEPARANSULFATE SSSNSS S -O-SerNS N-LINKEDCHAINS O-LINKEDCHAIN SAcP Proteoglycan GLYCOPHOSPHOLIPIDEtnANCHOR PNAsnNH2INOSITOL OSer/Thr NAsn GLYCOS...
Aebi, M. N-linked protein glycosylation in the ER. Biochim. Biophys. Acta 1833, 2430–2437 (2013). Article CAS Google Scholar Yan, A. & Lennarz, W. J. Unraveling the mechanism of protein N-glycosylation. J. Biol. Chem. 280, 3121–3124 (2005). Article CAS Google Scholar Tannous...
•UDP-Glc,UDP-Gal•UDP-GlcNAc,UDP-GalNAc•UDP-GlcA,UDP-Xyl•GDP-Man,GDP-Fuc •CMP-Sia(CMP-Neu5Ac)2.Givetherepresentationofthefollowingoligosaccharide:Chapter2 N-linkedGlycosylation AlleukaryoticcellsproduceN-glycans.N-linkedglycosylationisthebestunderstoodroutetoproteinglycosylation.Themolecular...
Above is a sample electrospray mass spectrum showing peaks that differ by 54 amu this is typical of a glycopeptide displaying mannose type glycosylation heterogeneity at the [M+3H]3+ charge state (see the chart above). To confirm the observation look for peaks that differ by 40.4 amu in the...
名词解释 N-linked glycosylation (N-连接糖基化) 答案: 新合成蛋白进行糖基化修饰的一种方式。糖通过与蛋白质的天冬氨酸的自由NH2基连接,所以将这种糖基化称为N-连接的糖基化。这... 点击查看完整答案 在线练习 手机看题 你可能感兴趣的试题 名词解释 heavy-chain binding protein, Bip (重链结合蛋白) ...
These data confirm that the WT protein contains glycosyl moieties linked to the N-glycosylation sites at residues N163 and N212. The same experiment was performed on protein extracted from rat kidney; also in this case, ASCT2 shows glycosylation moieties, similar to those of protein over-...