N-linked protein glycosylationWacker, MichaelNew Chemistry & New Opportunities from the Expanding Protein Universe
糖基的链接分为两种:① N-连接的糖基化(N-linked glycosylation):与天冬酰胺残基的NH₂连接,连接的糖为N-乙酰葡糖胺;② O-连接的糖基化(O-linked glycosylation):与Ser、Thr和Hyp的OH连接,连接的糖为半乳糖或N-乙酰半乳糖胺,在高尔基体上进行O-连接的糖基化。 三、泛素化 Ubiquitination 指泛素在一系列...
Protein N-linked glycosylation is a homologous process found both in eukaryotes and in prokaryotes. ? Prokaryotic N-glycan precursors are heter... F Schwarz,M Aebi - 《Current Opinion in Structural Biology》 被引量: 542发表: 2011年 Engineering N-linked protein glycosylation with diverse O ...
Protein glycosylation The polysaccharide structures found in Schizosaccharomyces pombe have been the subject of investigation for many years (Bush et al. 1974). This fission ye... Halina LIS,Nathan SHARON - 《European Journal of Biochemistry》 被引量: 849发表: 1993年 N-Linked Protein Glycosylation...
little is known aboutC. hepaticusglycosylation. In this study glycoproteomic analysis was used to confirm the functionality of theC. hepaticus N-glycosylation system. It was shown thatC. hepaticusHV10Tmodifies > 35 proteins with anN-linked heptasaccharide glycan.C. hepaticusshares highly conserv...
First definitive proof of N -linked protein glycosylation in bacteria and structural determination of the C. jejuni glycan. Article CAS PubMed Google Scholar Wacker, M. et al. N-linked glycosylation in Campylobacter jejuni and its functional transfer into E. coli. Science 298, 1790–1793 (...
Expanding the glycoengineering toolbox: the rise of bacterial N-linked protein glycosylation Glycosylation is the most prevalent post-translational modification found on proteins, occurring in all domains of life. Ever since the discovery of aspara... JL Baker,?elik, Eda,DeLisa, Matthew P. - 《Tr...
N-linked glycosylation is an important post-translational modification of proteins, mainly in eukaryotes. It involves the attachment of N-glycan chains toasparagine (Asn)residues of proteinsviaN-glycosidic bonds, usually on a specific sequence pattern Asn-X-Ser/Thr (where X represents any amino acid...
(2011) Mechanisms and principles of N-linked protein glycosylation. Curr. Opin. Struct. Biol. 21, 576-582 https://doi.org/10. 1016/j.sbi.2011.08.005Schwarz F and Aebi M. Mechanisms and principles of N-linked protein glycosylation. Current opinion in structural biology. 2011; 21(5):576-...
The activation of the HBP results in the production of UDP-N-acetylglucosamine, which is substrate for O-linked and N-linked glycosylation of proteins. Deficiency of GFPT1 results in structural changes in the end plate with loss of post-synaptic junctional folds and reduction in AChR expression,...