To elucidate the roles of O-GlcNAcylation in cancer, this review summarizes various cancer-associated biological events regulated by O-GlcNAcylation and the corresponding signaling pathways. This work may provide insights for future studies on the function or underlying mechanisms o...
In this review, we discuss the beneficial role and potential mechanisms by which O-GlcNAcylation promotes self-tolerance and maintains cellular homeostasis under stress conditions, with a focus on the cardiovascular and central nervous systems (CNS)....
nature nature reviews molecular cell biology review articles article Review Article Published: 10 May 2017 Protein O-GlcNAcylation: emerging mechanisms and functionsXiaoyong Yang & Kevin Qian Nature Reviews Molecular Cell Biology volume 18, pages 452–465 (2017)Cite this article ...
In this review, we briefly described recent progress demonstrating the neuroprotective effects of O-GlcNAcylation in a variety of neurodegenerative diseases. Our understanding of O-GlcNAcylation in the brain continues to evolve at a rapid pace, but its practical application for therapeutic goals is stil...
This review attempts to discuss these O-GlcNAcylation–dependent biochemical events involved in immune cell signaling, reiterate the known roles of O-GlcNAcylation, tries to derive knowledge relevant to the immune cells from its role in nonimmune cells and raises some plausible questions with potential...
Other observations suggest that elevating O-GlcNAc levels may decrease protein clearance or induce apoptosis. This review highlights some of the key findings regarding O-GlcNAcylation in models of neurodegenerative diseases. Previous article in issue Next article in issue Keywords OGT OGA Tau Synuclein ...
This review highlights the latest progress and potential mechanisms of O-GlcNAcylation in the regulation of skeletal muscle contraction and structural properties. Keywords: O-GlcNAc; skeletal muscle; metabolism; insulin resistance; sarcomere contraction and structure 1. Introduction The proteome is ...
By synthesizing current research, this review elucidates the multifaceted roles of O‐GlcNAcylation, providing a comprehensive reference for future studies. It underscores the potential of targeting the O‐GlcNAcylation cycle in developing novel therapeutic strategies for various pathologies. Abstract The ...
In this review, the current understanding of OGlcNAcylation and its adaptive modulation in immune and inflammatory responses is summarized. 展开 关键词: O-GlcNAcylation O-linked N-acetylglucosamine transferase O-GlcNAcase immunity inflammation DOI: 10.3892/ijmm.2019.4238 年份: 2019 ...
Review: protein O-GlcNAcylation regulates DNA damage response: a novel target for cancer therapy. Int J Biol Macromol. 2024;264(Pt 1):130351. Article CAS PubMed Google Scholar Yang R, Wang L, Wu Z, Yin Y, Jiang SW. How nanotechniques could vitalize the O-GlcNAcylation-Targeting ...