A single pair of enzymes - O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) - controls the dynamic cycling of this protein modification in a nutrient-and stress-responsive manner. Recent years have seen remarkable advances in our understanding of O-GlcNAcylation at levels that range from ...
收到该Mouse Protein O-GlcNAcase / MGEA5 (OGA) CLIA Kit产品后,按照试剂盒手册中的储存说明储存试剂盒。其他 Abbexa总部位于英国剑桥的剑桥科学园,是一家专业的全球抗体供应商和蛋白质供应商,致力于为生命科学、药物开发和生物技术领域的科学家和研究者提供最佳的客户体验和高质量的产品。产品涵盖一抗、二抗、...
J. et al. Structure and mechanism of a bacterial β-glucosaminidase having O-GlcNAcase activity. Nat. Struct. Mol. Biol. 13, 365–371 (2006). Article CAS PubMed Google Scholar Rao, F. V. et al. Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis. ...
O-GlcNAcylation is a post-translational modification of protein in response to genetic variations or environmental factors, which is controlled by two highly conserved enzymes, i.e. O-GlcNAc transferase (OGT) and protein O-GlcNAcase (OGA). Protein O-GlcN
联系电话:13611715263021-58955995 联系邮箱:sales@medchemexpress.cn QQ:2881321772 微信: 产品属性 规格5 μg 数量货期:1-2天 产品说明 MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。 O-GlcNAcase/OGA Protein, B. thetaiotaomicron (His) ...
Therefore, the purpose of the present study was to examined the acute (6 hours) effects of increasing protein O-GlcNAcylation on global gene expression in neonatal rat ventricular cardiomyocyte (NRVMs), by activating the hexosamine biosynthesis pathway (5mM glucosamine), or inhibiting O-GlcNAcase ...
Streptozotocin inhibits O-GlcNAcase via the production of a transition state analog. a number of proteins in a vast amount of cellular processes, this shift in whole-cell protein O-GlcNAcylation state affords another source of cell death... C Toleman,AJ Paterson,R Shin,... - 《Biochemical &...
Developmental Regulation of Protein O-GlcNAcylation, O-GlcNAc Transferase, and O-GlcNAcase in Mammalian Brain. Developmental Regulation of Protein O-GlcNAcylation, O-GlcNAc Transferase, and O-GlcNAcase in Mammalian Brain.doi:10.1371/journal.pone.0043724... - 《Plos One》 被引量: 0发表: 2012年 ...
1)10. The reverse reaction is catalyzed by β-N-acetylglucosaminidase or O-GlcNAcase (OGA; Fig. 1)11. Thus, O-GlcNAcylation competes with phosphorylation for the same residues to regulate protein function and a wide spectrum of cellular signaling and biological activities12,13,14,15. O-...
Due to the rapid concurrent removal by the single-GlcNAcase (OGA), precise functional dissection of site-specific-GlcNAc modification in vivo is currently not possible without affecting the entire-GlcNAc proteome. Exploiting the fortuitous promiscuity of OGT, we show that-GlcNAc is a hydrolytically ...