Protein O-GlcNAcylation in diabetes and diabetic complications . Expert review of proteomics , 10 : 365-380Ma J, Hart GW. Protein O-GlcNAcylation in diabetes and diabetic complications. Expert Rev Proteomics. 2013; 10 :365–380. doi: 10.1586/14789450.2013.820536. [ Cross Ref ]...
Maintenance of O-GlcNAc homeostasis is essential for optimal cellular function, and disruption of the cellular O-GlcNAcylation 'buffer' may contribute to the pathogenesis of various human diseases. O-GlcNAcylation can be viewed as the essential 'grease and glue' of the cell: it acts as a '...
O-GlcNAcylation is a post-translational modification of protein in response to genetic variations or environmental factors, which is controlled by two highly conserved enzymes, i.e. O-GlcNAc transferase (OGT) and protein O-GlcNAcase (OGA). Protein O-GlcN
Protein O-GlcNAcylation: a new signaling paradigm for the cardiovascular system The posttranslational modification of serine and threonine residues of nuclear and cytoplasmic proteins by the O-linked attachment of the monosaccharide be... B Laczy,BG Hill,W Kai,... - 《Am J Physiol Heart Circ ...
Conclusions Enhancing protein O-GlcNAcylation represents a novel approach to minimize cell death in CPCs. Such approaches could be explored with the goal of improving CPC survival at the time of adoptive transfer to bolster the reparative capacity of CPCs in vivo . Financial support: NIH, AHA....
The posttranslational modification of serine and threonine residues of nuclear and cytoplasmic proteins by the O-linked attachment of the monosaccharide beta-N-acetylglucosamine (O-GlcNAc) is a highly dynamic and ubiquitous protein modification. Protein O-GlcNAcylation is rapidly emerging as a key regula...
Thus, we report the primary demonstration of protein O-GlcNAcylation as an important pro-survival signal in CSCs, which could enhance CSC survival prior to in vivo autologous transfer. 展开 关键词: Adult stem cells Cardiac Cell biology Hypoxia ...
As reported in AD, defective HBP is responsible for flawed protein O‐GlcNAcylation coupled by a mutual inverse increase of protein phosphorylation on Ser/Thr residues, which gives to O‐GlcNAcylation the ability to modulate various pathways involved in AD progression. Previous studies have shown the...
磷酸化(phosphorylation)、糖基化(O-GlcNAcylation)、瓜氨酸化(citrullination)以及衣康酰化(itaconation)。除赖氨酸可被广泛的进行酰化修饰以外,丝氨酸和苏氨酸可被广泛的进行磷酸化和糖基化修饰(图2)。ATP介导的组蛋白磷酸化与肿瘤...
O-GlcNAcylation often modulates protein phosphorylation and regulates several cellular signaling and functions, especially in the brain. However, its developmental regulation is not well known. Here, we studied protein O-GlcNAcylation, OGT, and OGA in the rat brain at various ages from embryonic day...